Drug Interactions between Lunesta and Sulfatrim Pediatric
This report displays the potential drug interactions for the following 2 drugs:
- Lunesta (eszopiclone)
- Sulfatrim Pediatric (sulfamethoxazole/trimethoprim)
Interactions between your drugs
No interactions were found between Lunesta and Sulfatrim Pediatric. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Lunesta
A total of 369 drugs are known to interact with Lunesta.
- Lunesta is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Lunesta is used to treat Insomnia.
Sulfatrim Pediatric
A total of 412 drugs are known to interact with Sulfatrim Pediatric.
- Sulfatrim pediatric is in the drug class sulfonamides.
-
Sulfatrim pediatric is used to treat the following conditions:
- Bacterial Infection
- Bacterial Skin Infection
- Bronchitis
- Diverticulitis
- Epiglottitis
- Granuloma Inguinale
- Infection Prophylaxis
- Kidney Infections
- Melioidosis
- Meningitis
- Nocardiosis
- Otitis Media
- Pneumocystis Pneumonia
- Pneumocystis Pneumonia Prophylaxis
- Pneumonia
- Prevention of Bladder infection
- Prostatitis
- Shigellosis
- Sinusitis
- Toxoplasmosis
- Toxoplasmosis, Prophylaxis
- Traveler's Diarrhea
- Upper Respiratory Tract Infection
- Urinary Tract Infection
Drug and food interactions
eszopiclone food
Applies to: Lunesta (eszopiclone)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of zopiclone and eszopiclone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
ADJUST DOSING INTERVAL: Administration of eszopiclone (the S-enantiomer of zopiclone) with or immediately after a high-fat/heavy meal may delay the onset of hypnotic effects. In healthy adults, administration of a 3 mg dose of eszopiclone after a high-fat meal decreased the mean peak plasma drug concentration (Cmax) by 21% and delayed the time to reach peak plasma drug concentration (Tmax) by approximately 1 hour. Theoretically, this interaction should also affect racemic zopiclone.
MANAGEMENT: Patients receiving zopiclone or eszopiclone should be advised to avoid consumption of alcohol. For faster sleep onset, eszopiclone and zopiclone should not be administered with or immediately after a high-fat/heavy meal.
References
- "Product Information. Lunesta (eszopiclone)." Sepracor Inc (2004):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
sulfamethoxazole food
Applies to: Sulfatrim Pediatric (sulfamethoxazole / trimethoprim)
MONITOR: Two cases have been reported in which patients on sulfamethoxazole-trimethoprim therapy, after consuming beer, reported flushing, heart palpitations, dyspnea, headache, and nausea (disulfiram - alcohol type reactions). First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol by inhibiting acetaldehyde dehydrogenase and subsequently causing acetaldehyde accumulation. Since sulfamethoxazole is chemically related to first-generation sulfonylureas, a disulfiram-like reaction with products containing sulfamethoxazole is theoretically possible. However, pharmacokinetic/pharmacodynamic data are lacking and in addition, the two reported cases cannot be clearly attributed to the concomitant use of sulfamethoxazole-trimethoprim and alcohol.
MANAGEMENT: Patients should be alerted to the potential for this interaction and although the risk for this interaction is minimal, caution is recommended while taking sulfamethoxazole-trimethoprim concomitantly with alcohol.
References
- Heelon MW, White M "Disulfiram-cotrimoxazole reaction." Pharmacotherapy 18 (1998): 869-70
- Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA "Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions." Antimicrob Agents Chemother 64 (2020): e02167-19
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.