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Drug Interactions between Jalyn and peanut allergen powder

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

tamsulosin peanut allergen extract

Applies to: Jalyn (dutasteride / tamsulosin) and peanut allergen powder

GENERALLY AVOID: Alpha-adrenergic blockers and ergot alkaloids may attenuate the response to epinephrine in the treatment of serious systemic reactions, including anaphylaxis, that may occur during immunotherapy with allergenic extracts. Specifically, alpha-adrenergic blockers may antagonize the vasoconstricting and hypertensive effects of epinephrine, while ergot alkaloids can reverse the pressor effects of epinephrine.

MANAGEMENT: Immunotherapy with allergenic extracts may not be appropriate in patients receiving alpha-adrenergic blockers or ergot alkaloids, as these patients may be unresponsive to the usual doses of epinephrine required to reverse a systemic reaction.

References

  1. (2014) "Product Information. Grastek (timothy grass pollen allergen extract)." Merck & Co., Inc
  2. (2014) "Product Information. Ragwitek (ragweed pollen allergen extract)." Merck & Co., Inc
  3. (2014) "Product Information. Oralair (mixed grass pollens allergen extract)." Greer Laboratories Inc
  4. (2023) "Product Information. Palforzia (peanut allergen extract)." Aimmune Therapeutics
  5. (2022) "Product Information. Palforzia Level 1 (peanut allergen extract)." Aimmune Therapeutics UK Ltd
View all 5 references

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Drug and food interactions

Major

peanut allergen extract food

Applies to: peanut allergen powder

ADJUST DOSING INTERVAL: Coadministration of peanut allergen extract with alcohol may potentiate the risk of allergic reactions, including anaphylaxis. According to some studies, alcohol is an augmenting factor influencing immunological mechanisms that can induce more severe allergic reactions and is involved in up to 15% of cases of anaphylactic reactions. Proposed mechanisms include an increase in allergen absorption from altered permeability of the intestinal epithelial barrier, enhancing mast cell and basophil activation, and an increase in serum IgE concentrations. In addition, according to product labeling, administration of peanut allergen extract during a fasting state may potentiate the risk of allergic reactions, including anaphylaxis. The exact mechanism has not been elucidated.

MANAGEMENT: To minimize the risk of allergic reactions, including anaphylaxis, some authorities recommend alcohol not be consumed for 2 hours before, or 2 hours after taking peanut allergen extract. If alcohol cannot be avoided, withholding or decreasing peanut allergen dosage should be considered. Peanut allergen extract should also be administered with an evening meal and not within 2 hours of bedtime.

References

  1. (2023) "Product Information. Palforzia (peanut allergen extract)." Aimmune Therapeutics
  2. (2022) "Product Information. Palforzia Level 1 (peanut allergen extract)." Aimmune Therapeutics UK Ltd
  3. Munoz-Cano R, Pascal M, Araujo G, et al. (2023) Mechanisms, Cofactors, and Augmenting Factors Involved in Anaphylaxis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623009/pdf/fimmu-08-01193.pdf

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Moderate

tamsulosin food

Applies to: Jalyn (dutasteride / tamsulosin)

ADJUST DOSING INTERVAL: Food may delay the gastrointestinal absorption of tamsulosin. The time to maximum plasma concentration (Tmax) is reached by 4 to 5 hours under fasted conditions and by 6 to 7 hours when tamsulosin is administered with food. The delay in Tmax has the desirable effect of smoothing the tamsulosin plasma concentration profile, thereby reducing fluctuation of the plasma peak and trough concentrations with multiple dosing. Food may also affect the extent of absorption of tamsulosin. It has been reported that taking tamsulosin under fasted conditions results in a 30% increase in bioavailability (AUC) and 40% to 70% increase in peak plasma concentration (Cmax) compared to fed conditions. The effects of food on the pharmacokinetics of tamsulosin are consistent regardless of whether tamsulosin is taken with a light meal or a high-fat meal.

MANAGEMENT: To ensure uniformity of absorption, tamsulosin should be administered approximately one-half hour following the same meal each day.

References

  1. (2001) "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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