Drug Interactions between green tea and rosuvastatin
This report displays the potential drug interactions for the following 2 drugs:
- green tea
- rosuvastatin
Interactions between your drugs
green tea rosuvastatin
Applies to: green tea and rosuvastatin
Coadministration with epigallocatechin-3-gallate (EGCG), the most abundant and biologically active catechin in green tea, has been shown to modestly decrease the oral bioavailability of rosuvastatin. The mechanism of interaction has not been established, but may involve inhibition of organic anion transporting polypeptide (OATP) 1A2- and/or 2B1-mediated uptake of rosuvastatin in the intestine by EGCG. In a study with 13 healthy volunteers, administration of a single 20 mg dose of rosuvastatin in combination with 300 mg of EGCG (estimated in the study to be at least twice the amount contained in one cup of green tea) decreased rosuvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) by 15% and 19%, respectively, compared to administration of rosuvastatin alone. By contrast, administration of the same dose of rosuvastatin following 10 days of pretreatment with 300 mg EGCG had no significant effect on the pharmacokinetics of rosuvastatin. It was suggested by the investigators of the study that chronic administration of EGCG may inhibit both the absorption (via intestinal OATP 1A2 and/or 2B1) and elimination (via hepatic OATP 1B1 and/or 2B1) of rosuvastatin, resulting in no net changes in plasma concentrations of rosuvastatin. Presumably, low bioavailability of EGCG and its accumulation with multiple-dose administration may be responsible for the difference in pharmacokinetics of rosuvastatin between single dosing and chronic dosing of EGCG, with plasma concentrations of EGCG after single dosing not being sufficient to inhibit hepatic uptake of rosuvastatin. It is not known whether an interaction may occur with green tea extracts or infusions, which contain additional catechins that may contribute to further inhibition of transporters.
References
- Roth M, Timmermann BN, Hagenbuch B (2011) "Interactions of green tea catechins with organic anion-transporting polypeptides." Drug Metab Dispos, 39, p. 920-6
- Knop J, Misaka S, Singer K, et al. (2015) "Inhibitory effects of green tea and (-)-epigallocatechin gallate on transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein." PLoS One, 10, e0139370
- Kim TE, Ha N, Kim Y, et al. (2017) "Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers." Drug Des Devel Ther, 11, p. 1409-16
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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