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Drug Interactions between gadoxetate disodium and rifabutin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

rifabutin gadoxetate

Applies to: rifabutin and gadoxetate disodium

MONITOR: Anionic drugs such as rifamycins may interfere with the hepatic contrast enhancement of gadoxetate by competing for biliary excretion. In animal studies, rifampin blocked the hepatic uptake and decreased the hepatic contrast effect of gadoxetate. The interaction has not been studied in human.

MANAGEMENT: Clinicians should be aware of possible interference with gadoxetate imaging in patients receiving rifamycin therapy.

References

  1. (2008) "Product Information. Eovist (gadoxetate)." Bayer Pharmaceutical Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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