Drug interactions between Depakote and Topamax
Results for the following 2 drugs: |
|
|---|---|
| Depakote (divalproex sodium) | |
| Topamax (topiramate) | |
Interactions between your selected drugs
divalproex sodium ⇔ topiramate
Applies to: Depakote (divalproex sodium) and Topamax (topiramate)
MONITOR: Coadministration of topiramate with valproic acid has been reported to decrease mean area under the plasma concentration-time curve (AUC) of valproic acid by 11% and that of topiramate by 14%. The mechanism of interaction may involve increased metabolism of both drugs.
MANAGEMENT: Pharmacologic response to the drugs should be monitored more closely following addition or withdrawal of one or the other drug. Dose adjustments may be required if an interaction is suspected. Patients should be advised to notify their physician if they experience loss of seizure control.
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