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Drug Interactions between Clinoril and dimethyl sulfoxide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sulindac dimethyl sulfoxide

Applies to: Clinoril (sulindac) and dimethyl sulfoxide

GENERALLY AVOID: Dimethyl sulfoxide (DMSO) may reduce serum concentrations of the active metabolite, sulindac sulfide, by inhibiting sulindac reductase. The therapeutic effect of sulindac may be reduced. In addition, concomitant use of these agents has been reported to cause peripheral neuropathy. The mechanism is unknown.

MANAGEMENT: It may be advisable to avoid this drug combination.

References

  1. Swanson BN, Boppana Vk, Vlasses PH, Rotmensch HH, Ferguson RK "Dimethyl sulfoxide inhibits bioactivation of sulindac." J Lab Clin Med 102 (1983): 95-101
  2. Reinstein L, Mahon R, Russso GL "Peripheral neuropathy after concomitant dimethyl sulfoxide use and sulindac therapy." Arch Phys Med Rehabil 63 (1982): 581-4
  3. Swanson BN, Ferguson RK, Raskin NH, Wolf BA "Peripheral neuropathy after concomitant administration of dimethyl sulfoxide and sulindac." Arthritis Rheum 26 (1983): 791-3
  4. "Product Information. Clinoril (sulindac)." Merck & Co., Inc PROD (2001):
  5. Cerner Multum, Inc. "Australian Product Information." O 0
View all 5 references

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Drug and food interactions

Moderate

sulindac food

Applies to: Clinoril (sulindac)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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