Drug interactions between clarithromycin and Singulair
Results for the following 2 drugs: |
|
|---|---|
| clarithromycin | |
| Singulair (montelukast) | |
Interactions between your selected drugs
clarithromycin ⇔ montelukast
Applies to: clarithromycin and Singulair (montelukast)
The coadministration with drugs that are inhibitors of the CYP450 3A4 and/or 2C9 enzymatic pathways may increase the plasma concentrations of montelukast, which is metabolized by both of these isoenzymes. While clinical data are lacking, the possibility of prolonged and/or increased pharmacologic effects of montelukast should be considered. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever a CYP450 3A4 and/or 2C9 inhibitor is added to or withdrawn from therapy.
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