Drug Interactions between cephalexin and Iclusig
This report displays the potential drug interactions for the following 2 drugs:
- cephalexin
- Iclusig (ponatinib)
Interactions between your drugs
No interactions were found between cephalexin and Iclusig. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
cephalexin
A total of 37 drugs are known to interact with cephalexin.
- Cephalexin is in the drug class first generation cephalosporins.
- Cephalexin is used to treat the following conditions:
Iclusig
A total of 566 drugs are known to interact with Iclusig.
- Iclusig is in the following drug classes: BCR-ABL tyrosine kinase inhibitors, multikinase inhibitors, VEGF/VEGFR inhibitors.
- Iclusig is used to treat the following conditions:
Drug and food interactions
PONATinib food
Applies to: Iclusig (ponatinib)
GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of ponatinib, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: The consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit extract should be avoided during treatment with ponatinib.
References
- "Product Information. Iclusig (ponatinib)." Ariad Pharmaceuticals Inc (2012):
cephalexin food
Applies to: cephalexin
ADJUST DOSING INTERVAL: Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or cephradine. In one pharmacokinetic study (n=12), concurrent administration of zinc sulfate (250 mg, single oral dose) and cephalexin (500 mg, single oral dose) decreased cephalexin maximum concentration (Cmax) and systemic exposure (AUC; 0-inf) by 31.05% and 27.4%, respectively. However, in the same study, when zinc sulfate was administered 3 hours after the cephalexin dose, no significant alteration in cephalexin pharmacokinetics were observed.
MANAGEMENT: Oral medications or mineral supplements that contain zinc are recommended to be administered at least 3 hours after the cephalexin, ceftibuten or cephradine dose.
References
- Ding Y, Jia Y, Li F, et al. "The Effect of Staggered Administration of Zinc Sulfate on the Pharmacokinetics of Oral Cephalexin*" Br J Clin Pharmacol 73 (2011): 422-7
- World Health Organization "WHO Public Assessment Reports (WHOPARs) https://extranet.who.int/pqweb/medicines/prequalification-reports/whopars" (2020):
- Okamura M, Terada t, KatsuraT, Saito H, Inui K "Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2" Pharm Res 20 (2003): 1389-93
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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