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Drug Interactions between black cohosh and Platinol

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

CISplatin black cohosh

Applies to: Platinol (cisplatin) and black cohosh

GENERALLY AVOID: Preliminary data from an animal model suggest that black cohosh (Cimicifuga racemosa rhizome) may reduce the cytotoxic effect of cisplatin on breast cancer cells. Mouse mammary tumor cells exposed to a high concentration of black cohosh (Cimicifuga racemosa rhizome) (100 times the recommended dose) were found to be slightly more resistant to cisplatin than were cells treated with cisplatin alone or cisplatin plus vehicle. The clinical significance in humans is unknown.

MANAGEMENT: Until more data are available, investigators of the study suggest that patients with breast cancer be discouraged from taking black cohosh (Cimicifuga racemosa rhizome).

References

  1. Rockwell S, Liu Y, Higgins SA "Alteration of the effects of cancer therapy agents on breast cancer cells by the herbal medicine black cohosh." Breast Cancer Res Treat 90 (2005): 233-9

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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