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Drug Interactions between Bactocill and cholecalciferol / genistein / zinc chelazome

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

oxacillin genistein

Applies to: Bactocill (oxacillin) and cholecalciferol / genistein / zinc chelazome

Antibiotics may decrease the effects of soy isoflavones such as genistein and daidzein. Soy isoflavones are converted into their active forms in part by intestinal bacteria, thus alteration of the intestinal microflora by antibiotics may decrease availability of activated isoflavones. Data are limited. In a study consisting of 11 children ages 4 to 17 years who were fed a body weight-adjusted dose of soy nuts, the urinary excretion rates for genistein and all native isoflavones combined (i.e., genistein, daidzein, and glycitein) were reduced by 37% and 24%, respectively, during oral antibiotic treatment for infection compared to the healthy state when not on antibiotics. The urinary excretion rate for total isoflavones (i.e., native and activated isoflavones combined) was also reduced by 24% during antibiotic administration. The clinical significance of these changes is unknown. There was some indication that the infectious process itself may have played a role, either by altering the colonic flora or some other mechanism, although the extent is unclear.

References

  1. Therapeutic Research Faculty "Natural Medicines Comprehensive Database. http://www.naturaldatabase.com" (2008):
  2. Halm BM, Franke AA, Ashburn LA, Hebshi SM, Wilkens LR "Oral antibiotics decrease urinary isoflavonoid excretion in children after soy consumption." Nutr Cancer 60 (2008): 14-22

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Drug and food interactions

Moderate

oxacillin food

Applies to: Bactocill (oxacillin)

ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food. The therapeutic effect of the antimicrobial may be reduced.

MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

References

  1. Neu HC "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis 129 (1974): s123-31
  2. Welling PG, Huang H, Koch PA, Madsen PO "Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects." J Pharm Sci 66 (1977): 549-52
  3. McCarthy CG, Finland M "Absorption and excretion of four penicillins." N Engl J Med 263 (1960): 315-26
  4. Cronk GA, Wheatley WB, Fellers GF, Albright H "The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract." Am J Med Sci 240 (1960): 219-25
  5. Klein JO, Sabath LD, Finland M "Laboratory studies on oxacillin. I: in vitro activity against staphylococci and some other bacterial pathogens. II: absorption and urinary excretion in normal young." Am J Med Sci 245 (1963): 399-411
  6. Neuvonen PJ, Elonen E, Pentikainen PJ "Comparative effect of food on absorption of ampicillin and pivampicillin." J Int Med Res 5 (1977): 71-6
View all 6 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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