Drug Interactions between aspirin and Biaxin XL
This report displays the potential drug interactions for the following 2 drugs:
- aspirin
- Biaxin XL (clarithromycin)
Interactions between your drugs
No interactions were found between aspirin and Biaxin XL. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
aspirin
A total of 343 drugs are known to interact with aspirin.
- Aspirin is in the following drug classes: platelet aggregation inhibitors, salicylates.
-
Aspirin is used to treat the following conditions:
- Angina
- Angina Pectoris Prophylaxis
- Ankylosing Spondylitis
- Antiphospholipid Syndrome
- Aseptic Necrosis
- Back Pain
- Fever
- Heart Attack
- Ischemic Stroke
- Ischemic Stroke, Prophylaxis
- Juvenile Rheumatoid Arthritis
- Kawasaki Disease
- Lupus
- Myocardial Infarction, Prophylaxis
- Niacin Flush
- Osteoarthritis
- Pain
- Pain/Fever
- Prevention of Thromboembolism in Atrial Fibrillation
- Prosthetic Heart Valves - Thrombosis Prophylaxis
- Prosthetic Heart Valves, Mechanical Valves - Thrombosis Prophylaxis
- Revascularization Procedures, Prophylaxis
- Rheumatic Fever
- Rheumatoid Arthritis
- Sciatica
- Spondyloarthritis
- Thromboembolic Stroke Prophylaxis
- Transient Ischemic Attack
Biaxin XL
A total of 684 drugs are known to interact with Biaxin XL.
- Biaxin xl is in the drug class macrolides.
-
Biaxin xl is used to treat the following conditions:
- Bacterial Endocarditis Prevention
- Bronchitis
- Dental Abscess
- Helicobacter Pylori Infection
- Legionella Pneumonia
- Mycobacterium avium-intracellulare, Prophylaxis
- Mycobacterium avium-intracellulare, Treatment
- Mycoplasma Pneumonia
- Nongonococcal Urethritis
- Otitis Media
- Pertussis
- Pertussis Prophylaxis
- Pharyngitis
- Pneumonia
- Sinusitis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Strep Throat
- Tonsillitis/Pharyngitis
- Toxoplasmosis
- Upper Respiratory Tract Infection
Drug and food interactions
aspirin food
Applies to: aspirin
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
clarithromycin food
Applies to: Biaxin XL (clarithromycin)
Grapefruit juice may delay the gastrointestinal absorption of clarithromycin but does not appear to affect the overall extent of absorption or inhibit the metabolism of clarithromycin. The mechanism of interaction is unknown but may be related to competition for intestinal CYP450 3A4 and/or absorptive sites. In an open-label, randomized, crossover study consisting of 12 healthy subjects, coadministration with grapefruit juice increased the time to reach peak plasma concentration (Tmax) of both clarithromycin and 14-hydroxyclarithromycin (the active metabolite) by 80% and 104%, respectively, compared to water. Other pharmacokinetic parameters were not significantly altered. This interaction is unlikely to be of clinical significance.
References
- Cheng KL, Nafziger AN, Peloquin CA, Amsden GW "Effect of grapefruit juice on clarithromycin pharmacokinetics." Antimicrob Agents Chemother 42 (1998): 927-9
aspirin food
Applies to: aspirin
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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