Drug Interactions between Aspirin Low Strength and buspirone
This report displays the potential drug interactions for the following 2 drugs:
- Aspirin Low Strength (aspirin)
- buspirone
Interactions between your drugs
No interactions were found between Aspirin Low Strength and buspirone. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Aspirin Low Strength
A total of 343 drugs are known to interact with Aspirin Low Strength.
- Aspirin low strength is in the following drug classes: platelet aggregation inhibitors, salicylates.
-
Aspirin low strength is used to treat the following conditions:
- Angina
- Angina Pectoris Prophylaxis
- Heart Attack
- Ischemic Stroke
- Ischemic Stroke, Prophylaxis
- Myocardial Infarction, Prophylaxis
- Niacin Flush
- Prevention of Thromboembolism in Atrial Fibrillation
- Prosthetic Heart Valves - Thrombosis Prophylaxis
- Prosthetic Heart Valves, Mechanical Valves - Thrombosis Prophylaxis
- Revascularization Procedures, Prophylaxis
- Spondyloarthritis
- Thromboembolic Stroke Prophylaxis
- Transient Ischemic Attack
buspirone
A total of 496 drugs are known to interact with buspirone.
- Buspirone is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
-
Buspirone is used to treat the following conditions:
- Anxiety
- Borderline Personality Disorder (off-label)
- Panic Disorder
- Sexual Dysfunction, SSRI Induced (off-label)
Drug and food interactions
busPIRone food
Applies to: buspirone
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of buspirone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
ADJUST DOSING INTERVAL: In a small, randomized, crossover study, the consumption of large amounts of grapefruit juice (compared to water) was associated with significantly increased plasma buspirone concentrations, slightly prolonged elimination half-lives, and delayed times to reach peak drug concentration. The perceived pharmacodynamic effect of buspirone, as measured by subjective drowsiness and overall subjective drug effect, was also enhanced by grapefruit juice. These alterations may stem from the delay of gastric emptying as well as inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits.
MANAGEMENT: Patients receiving buspirone should be advised to avoid consumption of alcohol. Patients also should preferably avoid the consumption of large amounts of grapefruits and grapefruit juice to prevent any undue fluctuations in plasma drug levels. If this is not possible, the buspirone dose should be taken at least 2 hours before or 8 hours after grapefruit or grapefruit juice. Monitoring for increased CNS depression is recommended.
References
- "Product Information. Buspar (buspirone)." Bristol-Myers Squibb PROD (2002):
- Lilja JJ, Kivisto KT, Backman JT, Lamberg TS, Neuvonen PJ "Grapefruit juice substantially increases plasma concentrations of buspirone." Clin Pharmacol Ther 64 (1998): 655-60
- Bailey DG, Dresser GR, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients." Clin Pharmacol Ther 68 (2000): 468-77
aspirin food
Applies to: Aspirin Low Strength (aspirin)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
aspirin food
Applies to: Aspirin Low Strength (aspirin)
One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
References
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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