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Medications for Borderline Personality Disorder

Other names: BPD; EID; EIRD; Emotion-Impulse Regulation Disorder; Emotional Dysregulation Disorder; Emotional Intensity Disorder; Emotional Regulation Disorder; Emotionally Unstable Personality Disorder; ERD; EUPD; Impulsive Personality Disorder; IPD; Personality Disorder, Borderline

Borderline personality disorder (BPD) is a serious mental illness characterized by pervasive instability in moods, interpersonal relationships, self-image, and behavior.

Drugs used to treat Borderline Personality Disorder

The following list of medications are in some way related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
lamotrigine Off-label 7.9 101 reviews for lamotrigine to treat Borderline Personality Disorder
Rx C N X
Generic name:
lamotrigine systemic
Drug class:
triazine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
quetiapine Off-label 7.6 133 reviews for quetiapine to treat Borderline Personality Disorder
Rx C N X
Generic name:
quetiapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
buspirone Off-label 5.5 15 reviews for buspirone to treat Borderline Personality Disorder
Rx B N X
Generic name:
buspirone systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
fluoxetine Off-label 8.3 23 reviews for fluoxetine to treat Borderline Personality Disorder
Rx C N X
Generic name:
fluoxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
sertraline Off-label 6.8 40 reviews for sertraline to treat Borderline Personality Disorder
Rx C N X
Generic name:
sertraline systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
aripiprazole Off-label 6.9 42 reviews for aripiprazole to treat Borderline Personality Disorder
Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
lithium Off-label 7.0 18 reviews for lithium to treat Borderline Personality Disorder
Rx D N X
Generic name:
lithium systemic
Drug class:
antimanic agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
clonazepam Off-label 8.6 12 reviews for clonazepam to treat Borderline Personality Disorder
Rx D 4 X
Generic name:
clonazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
risperidone Off-label 5.1 28 reviews for risperidone to treat Borderline Personality Disorder
Rx C N X
Generic name:
risperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
olanzapine Off-label 7.5 39 reviews for olanzapine to treat Borderline Personality Disorder
Rx C N X
Generic name:
olanzapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
escitalopram Off-label 8.4 28 reviews for escitalopram to treat Borderline Personality Disorder
Rx C N X
Generic name:
escitalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
topiramate Off-label 6.8 21 reviews for topiramate to treat Borderline Personality Disorder
Rx D N X
Generic name:
topiramate systemic
Drug class:
carbonic anhydrase inhibitor anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
lorazepam Off-label 7.5 4 reviews for lorazepam to treat Borderline Personality Disorder
Rx D 4 X
Generic name:
lorazepam systemic
Drug class:
benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
diazepam Off-label 8.3 14 reviews for diazepam to treat Borderline Personality Disorder
Rx D 4 X
Generic name:
diazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
bupropion Off-label 7.8 9 reviews for bupropion to treat Borderline Personality Disorder
Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants, smoking cessation agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
alprazolam Off-label 5.0 2 reviews for alprazolam to treat Borderline Personality Disorder
Rx D 4 X
Generic name:
alprazolam systemic
Drug class:
benzodiazepines
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
divalproex sodium Off-label 5.2 9 reviews for divalproex sodium to treat Borderline Personality Disorder
Rx D N X
Generic name:
divalproex sodium systemic
Drug class:
fatty acid derivative anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
oxcarbazepine Off-label 7.3 11 reviews for oxcarbazepine to treat Borderline Personality Disorder
Rx C N X
Generic name:
oxcarbazepine systemic
Drug class:
dibenzazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
clozapine Off-label 8.5 6 reviews for clozapine to treat Borderline Personality Disorder
Rx B N X
Generic name:
clozapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
citalopram Off-label 7.7 12 reviews for citalopram to treat Borderline Personality Disorder
Rx C N X
Generic name:
citalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
lurasidone Off-label 7.9 24 reviews for lurasidone to treat Borderline Personality Disorder
Rx B N X
Generic name:
lurasidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
l-methylfolate Off-label 9.3 3 reviews for l-methylfolate to treat Borderline Personality Disorder
Rx/OTC N N
Generic name:
l-methylfolate systemic
Drug class:
vitamins
For consumers:
dosage, interactions, side effects
Off-label:
Yes
haloperidol Off-label 3.5 6 reviews for haloperidol to treat Borderline Personality Disorder
Rx C N X
Generic name:
haloperidol systemic
Drug class:
miscellaneous antipsychotic agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
carbamazepine Off-label 3.7 3 reviews for carbamazepine to treat Borderline Personality Disorder
Rx D N X
Generic name:
carbamazepine systemic
Drug class:
dibenzazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
asenapine Off-label 8.7 4 reviews for asenapine to treat Borderline Personality Disorder
Rx C N X
Generic name:
asenapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes

Frequently asked questions

Learn more about Borderline Personality Disorder

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.