Skip to main content

Drug Interactions between anagrelide and cilostazol

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

anagrelide cilostazol

Applies to: anagrelide and cilostazol

MONITOR: Anagrelide is an inhibitor of cyclic AMP phosphodiesterase (PDE) III and may potentiate the pharmacologic effects of drugs with similar properties such as inotropes milrinone, enoximone, inamrinone, olprinone, and cilostazol. Anagrelide alone has been associated with cardiovascular side effects such as vasodilation, palpitations, tachycardia, congestive heart failure, myocardial infarction, cardiomyopathy, cardiomegaly, complete heart block, and atrial fibrillation.

MANAGEMENT: Caution is advised if anagrelide is coadministered with other inotropes or PDE III inhibitors. The risk of potentially additive cardiovascular adverse effects should be considered.

References

  1. (2001) "Product Information. Agrylin (anagrelide)." Roberts Pharmaceutical Corporation

Switch to consumer interaction data

Drug and food interactions

Moderate

cilostazol food

Applies to: cilostazol

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of cilostazol. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

MANAGEMENT: Until more information is available, the manufacturer recommends avoiding consumption of grapefruit juice during cilostazol therapy. Orange juice is not expected to interact with cilostazol.

References

  1. (2001) "Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals Inc

Switch to consumer interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer