Generic Name: anagrelide (an AH gre lide)
Brand Name: Agrylin
What is anagrelide?
Anagrelide lowers the number of blood clotting cells (platelets) in the body, which helps prevent blood clots from forming.
Anagrelide is used to treat a condition called thrombocythemia (also called thrombocytosis). Thrombocythemia is a blood cell disorder in which too many platelet cells are produced, causing bleeding or blood-clotting problems.
Anagrelide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about anagrelide?
You should not use anagrelide if you have moderate to severe liver disease.
What should I discuss with my healthcare provider before taking anagrelide?
You should not use anagrelide if you are allergic to it, or if you have moderate to severe liver disease.
To make sure anagrelide is safe for you, tell your doctor if you have:
heart disease or congestive heart failure;
bleeding or blood clotting disorder such as hemophilia;
kidney disease; or
asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder.
FDA pregnancy category C. It is not known whether anagrelide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether anagrelide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using anagrelide.
How should I take anagrelide?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG) before you take this medicine.
While using anagrelide, you may need frequent blood tests. Your heart, liver, and kidney function may also need to be checked.
If you need surgery, tell the surgeon ahead of time that you are using anagrelide.
You should not stop using anagrelide suddenly. Stopping suddenly may make your condition worse.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking anagrelide?
Do not take aspirin unless your doctor has told you to. Follow your doctor's instructions about how much aspirin to take, and how often to take it.
Ask a doctor or pharmacist before using any other pain, cold, allergy, or sleep medication. Aspirin (sometimes abbreviated as ASA) is contained in many combination medicines. Although aspirin is sometimes prescribed for use with anagrelide, taking these medications together may increase your risk of bleeding. Check the label to see if a medicine contains aspirin or ASA.
Anagrelide side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
pounding heartbeats or fluttering in your chest;
shortness of breath (even with mild exertion), swelling, rapid weight gain;
sudden chest pain or discomfort, wheezing, dry cough or hack, feeling short of breath;
severe pain in your upper stomach spreading to your back, vomiting, fast heart rate;
chest pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling; or
sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
Common side effects may include:
mild or occasional headache;
diarrhea, stomach pain, gas, indigestion;
fever, sore throat, loss of appetite;
back pain; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: anagrelide side effects (in more detail)
Anagrelide Dosing Information
Usual Adult Dose for Thrombocythemia:
Initial: 0.5 mg orally 4 times a day, or 1 mg orally twice a day, for a minimum of 7 days.
Maintenance: titrate to the lowest effective dosage required to reduce and maintain the platelet count at less than 600,000 cells/microliter, ideally down to normal levels. Increase the dosage by no more than 0.5 mg/day in any 1 week period.
The dosage should not exceed 10 mg/day or 2.5 mg in any single dose.
Usual Pediatric Dose for Chronic Myelogenous Leukemia:
0.5 mg four times daily, to a maximum daily dose of 10 mg.
Usual Pediatric Dose for Thrombocythemia:
0.5 mg four times daily, to a maximum daily dose of 10 mg.
What other drugs will affect anagrelide?
Other drugs may interact with anagrelide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about anagrelide
- Other brands: Agrylin
Compare with other treatments for:
Where can I get more information?
- Your pharmacist can provide more information about anagrelide.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01. Revision Date: 2013-10-14, 10:51:01 PM.