Drug Interactions between albendazole and Levaquin
This report displays the potential drug interactions for the following 2 drugs:
- albendazole
- Levaquin (levofloxacin)
Interactions between your drugs
No interactions were found between albendazole and Levaquin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
albendazole
A total of 123 drugs are known to interact with albendazole.
- Albendazole is in the drug class anthelmintics.
-
Albendazole is used to treat the following conditions:
- Ascariasis
- Capillariasis
- Cutaneous Larva Migrans
- Cysticercus cellulosae
- Echinococcus
- Enterocolitis
- Filariasis, Elephantiasis
- Giardiasis
- Gnathostomiasis
- Hookworm Infection
- Hydatid Disease
- Liver Fluke
- Loiasis
- Microsporidiosis
- Neurocysticercosis
- Pinworm Infection
- Strongyloidiasis
- Trichinosis
- Trichostrongylosis
- Visceral Larva Migrans, Toxicariasis
- Whipworm Infection
Levaquin
A total of 500 drugs are known to interact with Levaquin.
- Levaquin is in the drug class quinolones and fluoroquinolones.
-
Levaquin is used to treat the following conditions:
- Anthrax
- Anthrax Prophylaxis
- Bacterial Infection
- Bladder Infection
- Bronchitis
- Chlamydia Infection
- Epididymitis, Sexually Transmitted
- Gonococcal Infection, Disseminated
- Gonococcal Infection, Uncomplicated
- Kidney Infections
- Nongonococcal Urethritis
- Nosocomial Pneumonia
- Otitis Media (off-label)
- Pelvic Inflammatory Disease
- Plague
- Plague Prophylaxis
- Pneumonia
- Prostatitis
- Sinusitis
- Skin or Soft Tissue Infection
- Streptococcal Infection
- Tuberculosis, Active
- Urinary Tract Infection
Drug and food interactions
albendazole food
Applies to: albendazole
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of albendazole, which is rapidly converted by hepatocytes and intestinal mucosal cells into the active metabolite, albendazole sulfoxide (ABZSX), following absorption. The proposed mechanism is stimulation of gastric acid secretion, as the absorption of albendazole is thought to be pH-dependent. According to the product labeling, plasma concentrations of ABZSX are up to 5-fold higher on average when albendazole is administered with a fatty meal (fat content approximately 40 g) compared to administration in the fasted state. In one study of six healthy male volunteers, administration of a single 10 mg/kg oral dose of albendazole in combination with a high-fat meal (57 g fat, 1399 kcal) increased the mean ABZSX peak plasma concentration (Cmax) and systemic exposure (AUC) by 6.5- and 9.4-fold, respectively, and delayed the time to reach Cmax (Tmax) from 2.5 to 5.3 hours compared to administration in the fasted state with water. The elimination half-life was not affected.
MONITOR: Grapefruit juice may increase the oral bioavailability of albendazole, which is rapidly converted by hepatocytes and intestinal mucosal cells into the active metabolite, albendazole sulfoxide (ABZSX), following absorption. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. In six healthy male volunteers, administration of a single 10 mg/kg oral dose of albendazole in combination with 250 mL of double-strength grapefruit juice increased the mean ABZSX peak plasma concentration (Cmax) and systemic exposure (AUC) by 3.2- and 3.1-fold, respectively, compared to administration with water. However, because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: To ensure maximal oral absorption, albendazole should be taken with food. Grapefruit juice may also enhance the oral bioavailability of albendazole.
References
- Awadzi K, Hero M, Opoku NO, Buttner DW, Coventry PA, Prime MA, Orme ML, Edwards G (1994) "The chemotherapy of onchocerciasis XVII. A clinical evaluation of albendazole in patients with onchocerciasis; effects of food and pretreatment with ivermectin on drug response and pharmacokinetics." Trop Med Parasitol, 45, p. 203-8
- (2001) "Product Information. Albenza (albendazole)." SmithKline Beecham
- Nagy J, Schipper HG, Koopmans RP, Butter JJ, van Boxtel CJ, Kager PA (2002) "Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability." Am J Trop Med Hyg, 66, p. 260-3
levoFLOXacin food
Applies to: Levaquin (levofloxacin)
ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of levofloxacin. According to the drug product labeling, administration of levofloxacin 500 mg with food prolonged the time to peak concentration by 1 hour and decreased the Cmax decreased by 25% following administration of the oral solution and by 14% following administration of the oral tablet.
MANAGEMENT: To ensure maximal and consistent oral absorption, levofloxacin oral solution should be taken at least one hour before or two hours after meals. For administration of the oral solution with continuous enteral nutrition, some experts recommend that the tube feeding should be interrupted for one hour before and two hours after the dose of levofloxacin. The oral tablets may be taken without regard to food.
References
- Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT (2009) "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm, 66, p. 1438-67
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.