Vitamin E Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Vitamin E Deficiency

Treatment: 60 to 75 units orally once daily.
Prevention: 30 units orally once daily.

Usual Adult Dose for Tardive Dyskinesia

600 to 1600 units orally per day.

Usual Adult Dose for Sickle Cell Anemia

450 units orally per day.

Usual Adult Dose for Alzheimer's Disease

1000 units orally twice daily.

Usual Adult Dose for Dietary Supplement

Oral liquid formulation (AQUA-E): 200 units (10 mL) orally once daily.

Usual Pediatric Dose for Vitamin E Deficiency

1 unit/kg/day orally of water-miscible vitamin E.

Usual Pediatric Dose for Retinopathy Prophylaxis

Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy: 15 to 30 units/kg/day to maintain plasma levels between 1.5 to 2 mcg/mL (may need as high as 100 units/kg/day). Note: AAP considers this use investigational and routine use is not recommended.

Usual Pediatric Dose for Cystic Fibrosis

100 to 400 units/day orally.

Usual Pediatric Dose for Dietary Supplement

Dosing: 1 unit vitamin E = 1 mg dl-alpha-tocopherol acetate.

Oral:
Adequate Intake (AI):
1 to less than 6 months: 4 units daily
6 to less than 12 months: 5 units daily

Recommended Daily Allowance (RDA):
1 to 3 years: 6 units daily
4 to 8 years: 7 units daily
9 to 13 years: 11 units daily
13 years and Older: 15 units daily

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Although no longer available in the U.S., vitamin E injectable administered intravenously to premature infants may result in a potentially fatal syndrome consisting of thrombocytopenia, hepatomegaly, splenomegaly, ascites, and renal, hepatic, and pulmonary dysfunction.

Oral administration of large doses (200 mg per day) of a hyperosmolar vitamin E preparation to low-birthweight infants has been associated with the development of necrotizing enterocolitis.

Dialysis

Data not available

Other Comments

The oral liquid formulation (AQUA-E [R]) is intended to enhance absorption in patients with conditions associated with malabsorption (e.g., Crohn's disease, ulcerative colitis ) or for patients who have difficulty swallowing capsules.

The oral liquid formulation (AQUA-E [R]) may be taken directly or mixed with water or other beverage. It must be shaken well prior to each use and refrigerated after opening.

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