Sargramostim Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Neutropenia Associated with Chemotherapy

250 mcg/m2/day IV over a 4 hour period beginning on or around day 11 or 4 days following the completion of induction chemotherapy, if the day 10 bone marrow is hypoplastic with < 5% blasts. If a second cycle of induction chemotherapy is needed, administer approximately 4 days after the completion of chemotherapy if the bone marrow is hypoplastic with < 5% blasts. Continue sargramostim until absolute neutrophil count (ANC) is greater than 1500 cells/mm3. For 3 consecutive days, or a maximum of 42 days.

Usual Adult Dose for Bone Marrow Transplantation - Myeloid Reconstruction

250 mcg/m2/day for 21 days as a 2 hour IV infusion beginning 2 to 4 hours after the autologous bone marrow infusion, at least 24 hours after the last dose of chemotherapy and 12 hours after the last dose of radiotherapy.

Usual Adult Dose for Bone Marrow Transplantation - Failure or Engraftment Delay

250 mcg/m2/day for 14 days as a 2 hour IV infusion. The dose can be repeated 7 days later if engraftment has not been achieved. If engraftment has not taken place after the second administration of sargramostim, a dose of 500 mcg/m2/day for 14 days may be administered beginning 7 days after the previous dose (14 days after the initial dose).

Usual Pediatric Dose for Aplastic Anemia

Sargramostim has not been FDA approved for use in pediatric patients (less than 18 years of age).

8 to 32 mcg/kg/day IV or subcutaneously, administered once a day.

Usual Pediatric Dose for Bone Marrow Transplantation

Sargramostim has not been FDA approved for use in pediatric patients (less than 18 years of age).

250 mcg/m2/day IV or subcutaneously, once a day for 21 days beginning 2 to 4 hours after the marrow infusion on day 0.

Usual Pediatric Dose for Neutropenia Associated with Chemotherapy

Sargramostim has not been FDA approved for use in pediatric patients (less than 18 years of age).

3 to 15 mcg/kg/day IV or subcutaneously, each day for 14 to 21 days. Maximum dose: 30 mcg/kg/day or 1500 mcg/m2/day.

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.

Dose Adjustments

If the ANC becomes > 20,000 cells/mm3 or if the patient's platelet count exceeds 500,000 cells/mm3, interrupt administration or reduce the dose by one half.

Dialysis

Data not available.

Other Comments

This product contains the preservative benzyl alcohol which has been associated with a fatal "gasping syndrome" in premature infants.

Hide
(web2)