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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for HIV Infection
25 mg orally once a day with a meal
Approved indication: For the treatment of HIV-1 infection, in combination with other antiretroviral agents, in antiretroviral treatment-naive patients with HIV-1 RNA less than or equal to 100,000 copies/mL at the start of therapy
Renal Dose Adjustments
Mild or moderate renal impairment: No adjustment recommended.
Severe renal impairment, end-stage renal disease: Caution recommended.
Liver Dose Adjustments
Mild or moderate hepatic impairment (Child-Pugh A or B): No adjustment recommended.
Severe hepatic impairment (Child-Pugh C): Data not available
Consult WARNINGS section for dosing related precautions.
Data not available
-Rilpivirine should be taken with a meal; a protein drink alone does not replace a meal.
-If a patient misses a dose of rilpivirine by more than 12 hours, the patient should not take the missed dose, but resume the usual dosing schedule.
-Antacids (e.g., aluminum or magnesium hydroxide, calcium carbonate) should be administered at least 2 hours before or at least 4 hours after rilpivirine.
-H2-receptor antagonists should be administered at least 12 hours before or at least 4 hours after rilpivirine.
Storage requirements: Tablets should be stored in original bottle to protect from light.
-General: Increase monitoring for side effects (with severe renal impairment or end-stage renal disease).
-Hepatic: Appropriate laboratory tests before therapy and monitor for hepatotoxicity during therapy (with underlying hepatic disease or marked baseline transaminase elevations); monitor liver enzymes (with no preexisting hepatic disease or other risk factors).
More about rilpivirine
- Other brands: Edurant