Rilpivirine Dosage

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for HIV Infection

25 mg orally once a day with a meal

Approved indication: For the treatment of HIV-1 infection, in combination with other antiretroviral agents, in antiretroviral treatment-naive patients with HIV-1 RNA less than or equal to 100,000 copies/mL at the start of therapy

Renal Dose Adjustments

Mild or moderate renal impairment: No adjustment recommended.
Severe renal impairment, end-stage renal disease: Caution recommended.

Liver Dose Adjustments

Mild or moderate hepatic impairment (Child-Pugh A or B): No adjustment recommended.
Severe hepatic impairment (Child-Pugh C): Data not available


Consult WARNINGS section for dosing related precautions.


Data not available

Other Comments

Administration advice:
-Rilpivirine should be taken with a meal; a protein drink alone does not replace a meal.
-If a patient misses a dose of rilpivirine by more than 12 hours, the patient should not take the missed dose, but resume the usual dosing schedule.
-Antacids (e.g., aluminum or magnesium hydroxide, calcium carbonate) should be administered at least 2 hours before or at least 4 hours after rilpivirine.
-H2-receptor antagonists should be administered at least 12 hours before or at least 4 hours after rilpivirine.

Storage requirements: Tablets should be stored in original bottle to protect from light.

-General: Increase monitoring for side effects (with severe renal impairment or end-stage renal disease).
-Hepatic: Appropriate laboratory tests before therapy and monitor for hepatotoxicity during therapy (with underlying hepatic disease or marked baseline transaminase elevations); monitor liver enzymes (with no preexisting hepatic disease or other risk factors).