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Praziquantel Dosage

This dosage information may not include all the information needed to use Praziquantel safely and effectively. See additional information for Praziquantel.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Nanophyetus salmincola

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Schistosoma japonicum

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Schistosoma mekongi

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Schistosoma haematobium

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Adult Dose for Schistosoma mansoni

20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Adult Dose for Fasciolopsis buski (Intestinal Fluke)

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Heterophyes heterophyes (Intestinal Fluke)

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Metagonimus yokogawai (Intestinal Fluke)

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Opisthorchis viverrini (Liver Fluke)

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Clornorchis sinensis (Liver Fluke)

25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Adult Dose for Paragonimus westermani (Lung Fluke)

25 mg/kg orally every 4 hours for 6 doses (3 doses per day for 2 consecutive days)

Case Report (n=1)
75 mg/kg/day for 3 days

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm)

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm)

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Taenia saginata (beef tapeworm)

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Taenia solium (pork tapeworm)

5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm)

25 mg/kg orally one time

Since eradication may be difficult, retreatment is recommended if the infection persists.

Usual Adult Dose for Cysticercus cellulosae (Cysticercosis)

50 mg/kg/day orally in 3 divided doses for 15 days

Concomitant use of corticosteroids during praziquantel therapy for neurocysticercosis may reduce the frequency and severity of an inflammatory response to degeneration of cysts in the central nervous system.

Repeated courses of therapy may be considered in patients with only partial resolution of cysts 3 months after a course or whose condition deteriorates.

Usual Adult Dose for Echinococcus Infection

Study (n=19)
50 mg/kg once daily, in combination with albendazole, to a maximum of 9 months

Patients unable to tolerate side effects took praziquantel once, twice weekly or once every two weeks.

Usual Pediatric Dose for Nanophyetus salmincola

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Schistosoma japonicum

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Schistosoma mekongi

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Schistosoma haematobium

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Pediatric Dose for Schistosoma mansoni

4 years or older: 20 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Some clinicians recommend 20 mg/kg orally every 4 hours for 2 doses (as a 1 day treatment).

Usual Pediatric Dose for Fasciolopsis buski (Intestinal Fluke)

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Heterophyes heterophyes (Intestinal Fluke)

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Metagonimus yokogawai (Intestinal Fluke)

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Opisthorchis viverrini (Liver Fluke)

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Clornorchis sinensis (Liver Fluke)

4 years or older: 25 mg/kg orally every 4 hours for 3 doses (as a 1 day treatment)

Usual Pediatric Dose for Paragonimus westermani (Lung Fluke)

4 years or older: 25 mg/kg orally every 4 hours for 6 doses (3 doses per day for 2 consecutive days)

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm)

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm)

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Taenia saginata (beef tapeworm)

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Taenia solium (pork tapeworm)

4 years or older: 5 to 10 mg/kg orally one time

Up to 20 mg/kg given once has been recommended in the past for the treatment of most tapeworms.

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm)

4 years or older: 25 mg/kg orally one time

Since eradication may be difficult, retreatment is recommended if the infection persists.

Usual Pediatric Dose for Cysticercus cellulosae (Cysticercosis)

4 years or older: 50 mg/kg/day orally in 3 divided doses for 15 days

Concomitant use of corticosteroids during praziquantel therapy for neurocysticercosis may reduce the frequency and severity of an inflammatory response to degeneration of cysts in the central nervous system.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

The manufacturer recommends caution when administering the usual recommended dose of this drug to hepatosplenic schistosomiasis patients with moderate to severe liver impairment (Child-Pugh class B and C).

Praziquantel undergoes extensive metabolism by the liver; however, it is unknown if doses should be adjusted for patients with liver disease receiving long-term treatment.

Dose Adjustments

Dosage reductions should be considered if recommended dosages are not tolerated by the patient.

Some clinicians recommend lower dosages (40 mg/kg given as a single dose or in 2 equally divided doses) for any patient with schistosomiasis since such dosages have been effective in some patients.

Precautions

Ocular cysticercosis must not be treated with praziquantel because parasite destruction within the eye may cause irreversible lesions.

Concomitant administration with strong CYP450 inducers (such as rifampin) is contraindicated since therapeutically effective blood levels of praziquantel may not be reached. Alternative agents should be considered in patients receiving rifampin who need immediate schistosomiasis treatment. If treatment with praziquantel is required, rifampin should be discontinued 4 weeks prior to praziquantel administration. Rifampin can be restarted one day following the completion of praziquantel therapy.

Patients suffering from cardiac irregularities should be monitored during therapy.

Clinical studies of praziquantel did not include a sufficient number of patients ages 65 and over to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between elderly and younger patients, but greater sensitivity of some older patients cannot be ruled out. Praziquantel is known to be substantially excreted by the kidney. Since elderly patients are more likely to have decreased renal function, the risk of toxic reactions to this drug may be greater in these patients.

Safety has not been established in pediatric patients less than 4 years of age.

Dialysis

No adjustment recommended.

Other Comments

The time interval between the individual doses should not be less than 4 hours and not greater than 6 hours.

Tablets or portions of tablets should be swallowed whole without chewing as the bitter taste may cause gagging or vomiting in some cases.

When schistosomiasis or fluke infection is found to be associated with cerebral cysticercosis, hospitalization of the patient for the duration of treatment is recommended.

The treatment of neurocysticercosis is associated with an inflammatory reaction due to the breakdown of parasites and release of antigenic substances. The administration of corticosteroids during praziquantel therapy is useful in controlling this reaction.

Praziquantel may cause dizziness or drowsiness and patients should be advised not to drive a car or operate heavy machinery during and for 24 hours after treatment.

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