Praziquantel Dosage

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Usual Adult Dose for Schistosoma japonicum

60 mg/kg/day orally in 2 or 3 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Adult Dose for Schistosoma mekongi

60 mg/kg/day orally in 2 or 3 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Adult Dose for Schistosoma haematobium

60 mg/kg/day orally in 3 divided doses or 40 mg/kg/day orally in 1 to 2 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Adult Dose for Schistosoma mansoni

60 mg/kg/day orally in 3 divided doses or 40 mg/kg/day orally in 1 to 2 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Adult Dose for Opisthorchis viverrini (Liver Fluke)

75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 to 2 days

Comments:
-Considered the drug of choice

Usual Adult Dose for Clornorchis sinensis (Liver Fluke)

75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 to 2 days

Comments:
-Considered the drug of choice

Usual Adult Dose for Fasciolopsis buski (Intestinal Fluke)

75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Adult Dose for Heterophyes heterophyes (Intestinal Fluke)

75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Adult Dose for Metagonimus yokogawai (Intestinal Fluke)

75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Adult Dose for Nanophyetus salmincola

60 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Adult Dose for Paragonimus westermani (Lung Fluke)

75 mg/kg/day orally in 3 divided doses
Duration of therapy: 2 days

Comments:
-Considered the drug of choice

Case Report (n=1)
75 mg/kg/day for 3 days

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm)

5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm)

5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Adult Dose for Taenia saginata (beef tapeworm)

5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Adult Dose for Taenia solium (pork tapeworm)

5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm)

25 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Adult Dose for Cysticercus cellulosae (Cysticercosis)

50 mg/kg/day orally
Duration of therapy: 15 days

Comments:
-For the tissue (larval) stage
-Recommended as alternative therapy
-The daily dose has been given in 3 divided doses.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Schistosoma japonicum

4 years or older: 60 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Pediatric Dose for Schistosoma mekongi

4 years or older: 60 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Pediatric Dose for Schistosoma haematobium

4 years or older: 60 mg/kg/day orally in 3 divided doses or 40 mg/kg/day orally in 2 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Pediatric Dose for Schistosoma mansoni

4 years or older: 60 mg/kg/day orally in 3 divided doses or 40 mg/kg/day orally in 2 divided doses
Duration of therapy: 1 day

Comments:
-Retreatment in 2 to 6 weeks has been reported to increase cure.
-Considered the drug of choice

Usual Pediatric Dose for Opisthorchis viverrini (Liver Fluke)

4 years or older: 75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 to 2 days

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Clornorchis sinensis (Liver Fluke)

4 years or older: 75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 to 2 days

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Fasciolopsis buski (Intestinal Fluke)

4 years or older: 75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Heterophyes heterophyes (Intestinal Fluke)

4 years or older: 75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Metagonimus yokogawai (Intestinal Fluke)

4 years or older: 75 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Nanophyetus salmincola

4 years or older: 60 mg/kg/day orally in 3 divided doses
Duration of therapy: 1 day

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Paragonimus westermani (Lung Fluke)

4 years or older: 75 mg/kg/day orally in 3 divided doses
Duration of therapy: 2 days

Comments:
-Considered the drug of choice

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm)

4 years or older: 5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm)

4 years or older: 5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Pediatric Dose for Taenia saginata (beef tapeworm)

4 years or older: 5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Pediatric Dose for Taenia solium (pork tapeworm)

4 years or older: 5 to 10 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm)

4 years or older: 25 mg/kg orally once

Comments:
-For the intestinal (adult) stage
-Considered the drug of choice

Usual Pediatric Dose for Cysticercus cellulosae (Cysticercosis)

4 years or older: 50 mg/kg/day orally
Duration of therapy: 15 days

Comments:
-For the tissue (larval) stage
-Recommended as alternative therapy
-The daily dose has been given in 3 divided doses.
-Current guidelines should be consulted for additional information.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Hepatosplenic schistosomiasis patients with moderate to severe liver dysfunction (Child-Pugh B and C): Usual dose should be used with caution.

Precautions

Safety has not been established in patients younger than 4 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Swallow tablets or portions of tablets whole without chewing; take with water during meals.
-The time interval between individual doses should not be less than 4 hours and not more than 6 hours.

General:
-When schistosomiasis or fluke infection is associated with cerebral cysticercosis, hospitalization of the patient for the duration of therapy is recommended.
-Tablets have 3 scores; each segment contains 150 mg of praziquantel. Portions are broken off by pressing the score with thumbnails; for 1/4 of a tablet, the portion from the outer end should be broken off.

Patient advice:
-Do not keep tablets or portions of tablets in your mouth; the bitter taste may cause gagging or vomiting.
-Do not drive or operate heavy machinery on the day of and during the 24 hours after treatment; the drug may cause dizziness or drowsiness.

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