Pomalyst Dosage

Generic name: pomalidomide
Dosage form: capsule

This dosage information does not include all the information needed to use Pomalyst safely and effectively. See full prescribing information for Pomalyst.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Multiple Myeloma

Females of reproductive potential must have negative pregnancy testing and use contraception methods before initiating POMALYST [see Warnings and Precautions (5.1) and Use in Specific Populations (8.6)].

The recommended starting dose of POMALYST is 4 mg once daily orally on Days 1-21 of repeated 28-day cycles until disease progression. POMALYST may be given in combination with dexamethasone [see Clinical Studies (14.1)].

POMALYST may be taken with water. Inform patients not to break, chew or open the capsules. POMALYST should be taken without food (at least 2 hours before or 2 hours after a meal).

Dose Adjustments for Toxicity

Table 1: Dose Modification Instructions for POMALYST for Hematologic Toxicities
*Note: ANC = Absolute Neutrophil Count
  Toxicity   Dose Modification
  Neutropenia
  • ANC* < 500 per mcL or Febrile neutropenia (fever more
    than or equal to 38.5°C and ANC < 1,000 per mcL)

  • ANC return to more than or equal to 500 per mcL

  Interrupt POMALYST treatment, follow CBC weekly.

  Resume POMALYST at 3 mg daily.
  • For each subsequent drop < 500 per mcL

  • Return to more than or equal to 500 per mcL
  Interrupt POMALYST treatment

  Resume POMALYST at 1 mg less than the previous dose
  Thrombocytopenia
  • Platelets < 25,000 per mcL

  • Platelets return to > 50,000 per mcL

  Interrupt POMALYST treatment, follow CBC weekly

  Resume POMALYST treatment at 3 mg daily
  • For each subsequent drop < 25,000 per mcL

  • Return to more than or equal to 50,000 per mcL
  Interrupt POMALYST treatment

  Resume POMALYST at 1 mg less than previous dose.

For other Grade 3 or 4 toxicities hold treatment and restart treatment at 1 mg less than the previous dose when toxicity has resolved to less than or equal to Grade 2 at the physician’s discretion.

To initiate a new cycle of POMALYST, the neutrophil count must be at least 500 per mcL, the platelet count must be at least 50,000 per mcL. If toxicities occur after dose reductions to 1 mg, then discontinue POMALYST.

Advanced Breast Cancer: Learn about treatments to improve quality of life. Click Here

Close
Hide
(web2)