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Penicillin G Benzathine Dosage

Medically reviewed by Drugs.com. Last updated on May 24, 2024.

Applies to the following strengths: 1,200,000 units/2 mL; 600,000 units/mL; 2,400,000 units/4 mL; 1,200,000 units; 2,400,000 units

Usual Adult Dose for Pharyngitis

1.2 million units IM as a single dose

Uses: For the treatment of mild to moderate upper respiratory tract infections (URTIs) due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

Infectious Diseases Society of America (IDSA) and American Heart Association (AHA) Recommendations: 1.2 million units IM as a single dose

Comments:

Usual Adult Dose for Upper Respiratory Tract Infection

1.2 million units IM as a single dose

Uses: For the treatment of mild to moderate upper respiratory tract infections (URTIs) due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

Infectious Diseases Society of America (IDSA) and American Heart Association (AHA) Recommendations: 1.2 million units IM as a single dose

Comments:

Usual Adult Dose for Tonsillitis/Pharyngitis

1.2 million units IM as a single dose

Uses: For the treatment of mild to moderate upper respiratory tract infections (URTIs) due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

Infectious Diseases Society of America (IDSA) and American Heart Association (AHA) Recommendations: 1.2 million units IM as a single dose

Comments:

Usual Adult Dose for Streptococcal Infection

1.2 million units IM as a single dose

Uses: For the treatment of mild to moderate upper respiratory tract infections (URTIs) due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

Infectious Diseases Society of America (IDSA) and American Heart Association (AHA) Recommendations: 1.2 million units IM as a single dose

Comments:

Usual Adult Dose for Rheumatic Fever Prophylaxis

1.2 million units IM once a month or 600,000 units IM every 2 weeks

Comments:


Uses: Prophylaxis against rheumatic fever and/or chorea recurrence; prophylaxis for rheumatic fever after an acute attack

AHA Recommendations: 1.2 million units IM every 3 to 4 weeks

Duration of secondary prophylaxis (after last attack):

Comments:

Usual Adult Dose for Syphilis - Early

2.4 million units IM as a single dose

Uses: For the treatment of primary, secondary, and latent syphilis

US CDC Recommendations:


Comments:

Usual Adult Dose for Syphilis - Latent

2.4 million units IM as a single dose

Uses: For the treatment of primary, secondary, and latent syphilis

US CDC Recommendations:


Comments:

Usual Adult Dose for Neurosyphilis

Bicillin L-A: 2.4 million units IM once a week for 3 doses
Permapen: 3 million units IM once a week for 2 to 3 doses (total dose: 6 to 9 million units)

Use: For the treatment of late syphilis (tertiary and neurosyphilis)

US CDC Recommendations:


Comments:

Usual Adult Dose for Tertiary Syphilis

Bicillin L-A: 2.4 million units IM once a week for 3 doses
Permapen: 3 million units IM once a week for 2 to 3 doses (total dose: 6 to 9 million units)

Use: For the treatment of late syphilis (tertiary and neurosyphilis)

US CDC Recommendations:


Comments:

Usual Adult Dose for Bejel

1.2 million units IM as a single dose

Usual Adult Dose for Yaws

1.2 million units IM as a single dose

Usual Adult Dose for Pinta

1.2 million units IM as a single dose

Usual Adult Dose for Glomerulonephritis

1.2 million units IM once a month or 600,000 units IM every 2 weeks

Comments:


Use: Prophylaxis for glomerulonephritis after an acute attack

Usual Pediatric Dose for Pharyngitis

Infants and pediatric patients less than 27.3 kg: 300,000 to 600,000 units IM as a single dose
Older pediatric patients: 900,000 units IM as a single dose

Uses: For the treatment of mild to moderate URTIs due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

IDSA Recommendations:


AHA and American Academy of Pediatrics (AAP) Recommendations:

Comments:

Usual Pediatric Dose for Upper Respiratory Tract Infection

Infants and pediatric patients less than 27.3 kg: 300,000 to 600,000 units IM as a single dose
Older pediatric patients: 900,000 units IM as a single dose

Uses: For the treatment of mild to moderate URTIs due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

IDSA Recommendations:


AHA and American Academy of Pediatrics (AAP) Recommendations:

Comments:

Usual Pediatric Dose for Tonsillitis/Pharyngitis

Infants and pediatric patients less than 27.3 kg: 300,000 to 600,000 units IM as a single dose
Older pediatric patients: 900,000 units IM as a single dose

Uses: For the treatment of mild to moderate URTIs due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

IDSA Recommendations:


AHA and American Academy of Pediatrics (AAP) Recommendations:

Comments:

Usual Pediatric Dose for Streptococcal Infection

Infants and pediatric patients less than 27.3 kg: 300,000 to 600,000 units IM as a single dose
Older pediatric patients: 900,000 units IM as a single dose

Uses: For the treatment of mild to moderate URTIs due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia)

IDSA Recommendations:


AHA and American Academy of Pediatrics (AAP) Recommendations:

Comments:

Usual Pediatric Dose for Rheumatic Fever Prophylaxis

AHA Recommendations:


Duration of secondary prophylaxis (after last attack):

Comments:

Usual Pediatric Dose for Congenital Syphilis

Less than 2 years: 50,000 units/kg IM as a single dose
2 to 12 years: Adjust dose based on adult dose schedule

Use: For the treatment of congenital syphilis (asymptomatic with normal CSF)

US CDC Recommendations:
Neonates:


Infants and children:

Maximum dose: 2.4 million units/dose

Comments:

Usual Pediatric Dose for Syphilis - Early

US CDC Recommendations:
1 month or older:

Maximum dose: 2.4 million units/dose

Maximum dose: 2.4 million units/dose (maximum total dose: 7.2 million units)

Comments:

Usual Pediatric Dose for Syphilis - Latent

US CDC Recommendations:
1 month or older:

Maximum dose: 2.4 million units/dose

Maximum dose: 2.4 million units/dose (maximum total dose: 7.2 million units)

Comments:

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

In children younger than 12 years, dose should be adjusted according to age and weight of the child and severity of the infection.

Precautions

US BOXED WARNING:


CONTRAINDICATIONS:
Previous hypersensitivity reaction to any of the penicillins

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.