Penicillin g benzathine Side Effects

Brand Names: Bicillin L-A

Please note - some side effects for Penicillin g benzathine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Penicillin g benzathine - for the Consumer

Penicillin g benzathine Suspension

Applies to: injection suspension

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Penicillin g benzathine Suspension:

Pain, swelling, or bleeding at the injection site; mild diarrhea; worsening of arthritis.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; blood in urine; bloody stools; chest pain; chills; extreme tiredness; fainting; fast heartbeat; fever; flushing with lightheadedness or fainting; hallucinations; headache; itching; muscle pain; nausea; pounding in the chest; rapid breathing; seizures; severe diarrhea; stomach pain/cramps; vaginal irritation or itching; vomiting; worsening of skin lesions.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: intramuscular suspension

Local

Local side effects have included injection site reactions, including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness or cyanosis of the extremities, and neurovascular damage have been reported.

Hypersensitivity

Hypersensitivity side effects have included skin eruptions (maculopapular to exfoliative dermatitis), pruritus, urticaria, laryngeal edema, fever, eosinophilia, hypersensitivity myocarditis, other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration), and anaphylaxis including shock and death. Hypersensitivity reactions including allergic vasculitis, pruritus, fatigue, asthenia, and pain have been reported. The Jarisch-Herxheimer reaction has been reported during syphilis treatment.

Cardiovascular

Cardiovascular side effects have included cardiac arrest, hypotension, tachycardia, palpitations, pulmonary hypertension, pulmonary embolism, vasodilatation, vasovagal reaction, and cerebrovascular accident.

Nervous system

Severe neurologic reactions were most often seen with penicillin doses of 18 million to 80 million units daily. These reactions frequently abated after discontinuation of penicillin. In several cases, penicillin was restarted at a lower dose with no further sequelae. In one review, the authors found that cerebral spinal fluid (CSF) penicillin levels were higher in patients with seizures than in those without. CSF penicillin levels ranged from 12 to 61 units/mL in the seizure group with the highest CSF concentrations, compared to 7.8 units/mL in the group without seizures.

Nervous system side effects have included syncope, neuropathy, headache, tremors, dizziness, somnolence, abnormal taste perception, tinnitus, transverse myelitis, seizures, aseptic meningitis, coma, and neurovascular reactions (including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage). Severe reactions (including myoclonus, seizures, auditory and visual hallucinations, and decreased mentation) have been reported with high dose penicillin therapy or in patients with renal dysfunction. Neurologic reactions occurred frequently in patients with renal dysfunction.

Gastrointestinal

Gastrointestinal side effects have included Clostridium difficile associated diarrhea and pseudomembranous colitis; onset may occur during or after therapy. Nausea, vomiting, pancreatitis, intestinal necrosis, and blood in the stool have been reported.

Hematologic

Hematologic side effects have included hemolytic anemia, anemia, leukopenia, thrombocytopenia, and lymphadenopathy.

Hepatic

A 28-year-old female developed jaundice, fever, epidermolysis, abnormal liver function tests, and cholestasis several days after receiving a single dose of penicillin intramuscularly. Her liver dysfunction continued for up to 18 months. She had taken acetaminophen concurrently but denied alcohol use.

Hepatic side effects have included increased SGOT, reversible hepatotoxicity, jaundice, and prolonged cholestasis.

Musculoskeletal

Musculoskeletal side effects have included joint disorder, periostitis, myoglobinuria, rhabdomyolysis, and exacerbation of arthritis. Quadriceps femoris fibrosis and atrophy have been reported following repeated intramuscular injections into the thigh.

Renal

Renal side effects have included increased BUN and creatinine, renal failure, and nephropathy.

Respiratory

Respiratory side effects have included hypoxia, apnea, and dyspnea.

Psychiatric

Psychiatric side effects have included nervousness, confusion, anxiety, and euphoria.

Ocular

Ocular side effects have included blurred vision and blindness.

Genitourinary

Genitourinary side effects have included neurogenic bladder, hematuria, proteinuria, impotence, and priapism.

Dermatologic

Dermatologic side effects have included diaphoresis, rash, peeling, mucosal ulceration, and urticaria.

Other

Other side effects have included fatigue, asthenia, pain, and aggravation of existing disorders.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.