Nisoldipine Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Angina Pectoris Prophylaxis

Slow release (old formulation):
Initial dose: 20 mg orally once a day
Maintenance dose: 10 to 60 mg orally once a day

Controlled release (new formulation):
Initial dose: 17 mg orally once a day
Maintenance dose: 8.5 to 34 mg orally once a day

Usual Adult Dose for Hypertension

Slow release (old formulation):
Initial dose: 20 mg orally once a day
Maintenance dose: 10 to 60 mg orally once a day

Controlled release (new formulation):
Initial dose: 17 mg orally once a day
Maintenance dose: 8.5 to 34 mg orally once a day

Usual Geriatric Dose for Angina Pectoris Prophylaxis

Slow release (old formulation);
Initial dose: 10 mg orally once a day
Maintenance dose: 10 to 60 mg orally once a day

Controlled release (new formulation):
Initial dose: 8.5 mg orally once a day
Maintenance dose: 8.5 to 34 mg orally once a day

Blood pressure should be monitored closely during any dosage adjustment.

Usual Geriatric Dose for Hypertension

Slow release (old formulation);
Initial dose: 10 mg orally once a day
Maintenance dose: 10 to 60 mg orally once a day

Controlled release (new formulation):
Initial dose: 8.5 mg orally once a day
Maintenance dose: 8.5 to 34 mg orally once a day

Blood pressure should be monitored closely during any dosage adjustment.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Slow release (old formulation);
Initial dose: 10 mg orally once a day
Maintenance dose: 10 to 60 mg orally once a day

Controlled release (new formulation):
Initial dose: 8.5 mg orally once a day
Maintenance dose: 8.5 to 34 mg orally once a day

Blood pressure should be monitored closely during any dosage adjustment.

Dose Adjustments

Slow release (old formulation):
Blood pressure response increases over the 10 to 60 mg daily dose range but adverse event rates also increase. Doses beyond 60 mg once daily are not recommended.

Controlled release (new formulation):
Blood pressure response increases over the 8.5 to 34 mg daily dose range but adverse event rates also increase. Doses beyond 34 mg once daily are not recommended.

Periodic monitoring of blood pressure has been recommended particularly during any dosage adjustment.

Precautions

Administration with a high fat meal can lead to excessive peak drug concentration and should be avoided.

Grapefruit products should be avoided before and after dosing.

Tablets should be swallowed whole, not bitten, divided, or crushed.

This product contains tartrazine, FD&C Yellow No 5, which may cause an allergic reaction, particularly in patients with aspirin hypersensitivity.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Slow release (old formulation):
Blood pressure response increases over the 10 to 60 mg daily dose range but adverse event rates also increase. Doses beyond 60 mg once daily are not recommended.

Controlled release (new formulation):
Blood pressure response increases over the 8.5 to 34 mg daily dose range but adverse event rates also increase. Doses beyond 34 mg once daily are not recommended.

Nisoldipine should be taken on an empty stomach, one hour before or two hours after a meal.

Periodic monitoring of blood pressure has been recommended particularly during any dosage adjustment.

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