Nicotine Dosage

This dosage information may not include all the information needed to use Nicotine safely and effectively. See additional information for Nicotine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Smoking Cessation

>100 lbs.:
Habitrol or NicoDerm CQ: 21 mg/day for 6 weeks, then 14 mg/day for 2 weeks, then 7 mg/day for 2 weeks.
Prostep: 22 mg/day for 4 to 8 weeks, then 11 mg/day for 2 to 4 weeks.
Nicotrol: 15 mg/day for 6 weeks. The dosage is delivered over 16 hours. The patch should not be left on > 16 hours.
Nicorette gum: 4 mg piece every 1 to 2 hours for 6 weeks, then 4 mg piece every 2 to 4 hours for 3 weeks, then 4 mg piece every 4 to 8 hours for 3 weeks. No more than 24 pieces/day. Chew gum slowly for at least 30 minutes. Should not be used > 6 months.
Commit lozenge: 2 to 4 mg lozenge every 1 to 2 hours in mouth until it dissolves (about 20 to 30 minutes). Use the recommended minimum of 9 lozenges/ day for 6 weeks, then 2 to 4 mg lozenge every 2 to 4 hours on weeks 7 through 9. At the start of week 10, reduce dosage to one lozenge every 4 to 8 hours. Do not use more than 20 lozenges/day. For use in a 12-week plan
Nicotrol NS: 1 to 2 mg/hour (2 to 4 sprays). Should use at least the recommended minimum dose of 8 doses/day. Maximum dose 40 mg (80 sprays)/day.
Nicotrol Inhaler: 6 to 16 cartridges per day for 3 months. Then, gradually reduce daily dose and taper patient off the inhaler over the next 6 to 12 weeks. Should not be used >6 months.

<100 lbs., light smokers, CV disease:
Habitrol or NicoDerm CQ: 14 mg/day for 6 weeks, then 7 mg/day for 2 weeks.
Prostep: 11 mg/day for 4 to 8 weeks.
Nicorette gum: 2 mg piece every 1 to 2 hours for 6 weeks, then 2 mg piece every 2 to 4 hours for 3 weeks, then 2 mg piece every 4 to 8 hours for 3 weeks. No more than 24 pieces/day. Chew gum slowly for at least 30 minutes. Should not be used >6 months.
Nicotrol NS: 1 to 2 mg/hour (2 to 4 sprays).
Nicotrol Inhaler: 6 to 16 cartridges per day for 3 months. Then, gradually reduce daily dose and taper patient off the inhaler over the next 6 to 12 weeks. Should not be used >6 months.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Start with lower doses if <100 lbs., light smoker (<10 cigarettes/day), or cardiovascular disease.

Precautions

Patients should be instructed not to sniff, swallow or inhale through the nose as the spray is being administered. The spray should be administered with the head tilted back slightly.

The use of Nicotrol NS is not recommended in patients with severe reactive airway disease or known chronic nasal disorders including allergies, rhinitis, nasal polyps and/or sinusitis.

The drug should also not be used in patients during the immediate post-myocardial infarction period, patients with serious arrhythmias, or with severe or worsening angina.

Nicotine gum should be used with caution in patients with a history of oral or pharyngeal inflammation or esophagitis. Use of nicotine gum may be problematic for patients with dental work.

Nicotine inhalation and nasal spray should be used with caution in patients with a history of bronchospastic airway disease. Other forms of nicotine replacement might be preferable in patients with severe bronchospastic airway disease.

Patients should be advised and encouraged to stop smoking completely before initiating nicotine replacement therapy.

Patients should be informed that higher than usual nicotine levels and adverse effects may occur if nicotine replacement products are used concurrently with smoking.

Replacement nicotine therapy should be used with caution in patients with cardiovascular or peripheral vascular disease, hyperthyroidism, pheochromocytoma, insulin-dependent diabetes or peptic ulcer disease.

Dialysis

Data not available

Other Comments

Nicotrol NS: each actuation contains 0.5 mg nicotine. One dose is 1 mg of nicotine (2 sprays, one in each nostril).

Although the use of nicotine preparations is not recommended in children and adolescents by the manufacturer, the US Public Health Service guidelines state that nicotine may be considered for the treatment of adolescents when there is evidence of dependence on nicotine and a desire to quit the use of tobacco.

Patients should be urged to stop smoking completely when initiating therapy. Patients should be instructed to apply the transdermal patch to a non-hairy, clean, dry area on the upper body or outer arm. Patch applications sites should be alternated and not reused for 1 week.

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