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Mafenide Topical Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Burns - External

Solution: Wet burn dressing with mafenide solution and cover grafted area. The dressing should be kept wet by injecting solution into irrigation tubing every 4 hours or moistening gauze dressing every 6 to 8 hours, as necessary.

Cream: Apply to cleaned and debrided burn(s) once or twice daily, at a thickness of not more than 1/16 inch. The cream should be reapplied whenever it is removed to keep burn(s) covered at all times. Thin layers of dressings may be used, if necessary. Treatment should continue until healing is progressing well or the skin is ready for grafting.

Usual Pediatric Dose for Burns - External

Solution:
>3 months: Wet burn dressing with mafenide solution and cover grafted area. The dressing should be kept wet by injecting solution into irrigation tubing every 4 hours or moistening gauze dressing every 6 to 8 hours, as necessary.

Cream: Apply to cleaned and debrided burn(s) once or twice daily, at a thickness of not more than 1/16 inch. The cream should be reapplied whenever it is removed to keep burn(s) covered at all times. Thin layers of dressings may be used, if necessary. Treatment should continue until healing is progressing well or the skin is ready for grafting.

Renal Dose Adjustments

Caution is recommended in burn patients with acute renal failure.

Liver Dose Adjustments

Data not available

Precautions

Mafenide should be discontinued if symptoms of hypersensitivity occur.

Acid-base balance should be closely monitored. Mafenide therapy should be interrupted for 24 to 48 hours if acidosis occurs and is difficult to control.

Dialysis

Data not available

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