Hydrochlorothiazide/Spironolactone Dosage
This dosage information may not include all the information needed to use Hydrochlorothiazide/Spironolactone safely and effectively. See additional information for Hydrochlorothiazide/Spironolactone.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 2 tablets (hydrochlorothiazide 25 mg-spironolactone 25 mg) orally once a day or 1 tablet (hydrochlorothiazide 50 mg-spironolactone 50 mg) orally once a day.
Maintenance dose: The initial dosage may be divided into two daily doses, and increased as tolerated approximately every two to four days to a maximum recommended total daily dose of hydrochlorothiazide 100 mg-spironolactone 100 mg.
Usual Adult Dose for Edema
Initial dose: 4 tablets (hydrochlorothiazide 25 mg-spironolactone 25 mg) orally once a day or 2 tablets (hydrochlorothiazide 50 mg-spironolactone 50 mg) orally once a day.
Maintenance dose: The initial dosage may be divided into two to four daily doses, and increased as tolerated approximately every two to four days to a maximum recommended total daily dose of hydrochlorothiazide 200 mg-spironolactone 200 mg. The risk of side effects increases significantly with dosages greater than the maximum recommended dose.
Usual Adult Dose for Congestive Heart Failure
Initial dose: 4 tablets (hydrochlorothiazide 25 mg-spironolactone 25 mg) orally once a day or 2 tablets (hydrochlorothiazide 50 mg-spironolactone 50 mg) orally once a day.
Maintenance dose: The initial dosage may be divided into two to four daily doses, and increased as tolerated approximately every two to four days to a maximum recommended total daily dose of hydrochlorothiazide 200 mg-spironolactone 200 mg. The risk of side effects increases significantly with dosages greater than the maximum recommended dose.
Usual Adult Dose for Ascites
Initial dose: 4 tablets (hydrochlorothiazide 25 mg-spironolactone 25 mg) orally once a day or 2 tablets (hydrochlorothiazide 50 mg-spironolactone 50 mg) orally once a day.
Maintenance dose: If there is inadequate diuresis after two to four days, this dosage should be increased as tolerated approximately every two to three days to a maximum recommended total daily dose of hydrochlorothiazide 200 mg-spironolactone 200 mg.
Usual Adult Dose for Nephrotic Syndrome
Initial dose: 4 tablets (hydrochlorothiazide 25 mg-spironolactone 25 mg) orally once a day or 2 tablets (hydrochlorothiazide 50 mg-spironolactone 50 mg) orally once a day.
Maintenance dose: The initial dosage may be divided into two to four daily doses, and increased as tolerated approximately every two to four days to a maximum recommended total daily dose of hydrochlorothiazide 200 mg-spironolactone 200 mg. The risk of side effects increases significantly with dosages greater than the maximum recommended dose.
Renal Dose Adjustments
CrCl less than 25 mL/min: Hydrochlorothiazide-spironolactone is not recommended in this patient with severe renal insufficiency since hydrochlorothiazide it is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 25 mL/min and spironolactone therapy is not recommended due to the risk of hyperkalemia in patients with moderate and severe renal dysfunction.
Liver Dose Adjustments
Since spironolactone is primarily metabolized, dose increments should be made cautiously in patients with liver disease. Frequent monitoring of the serum potassium is recommended.
Precautions
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
