Glucarpidase Dosage

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Methotrexate Overdosage

50 mg/kg intravenously one time.

Usual Pediatric Dose for Methotrexate Overdosage

50 mg/kg intravenously one time.

Renal Dose Adjustments

No adjustment to the starting dose is needed for patients with preexisting mild and moderate renal impairment.

Liver Dose Adjustments

No specific studies of glucarpidase in patients with hepatic impairment have been conducted.

Dose Adjustments

No dosage adjustment is recommended based on gender, weight, or geriatric status.


Serious allergic reactions (incidence greater than 1%), including anaphylactic reactions, may occur.

Do not administer leucovorin within 2 hours before or after a dose of glucarpidase.

Continue hydration and alkalinization of the urine as indicated.


Data not available.

Other Comments

Store glucarpidase at 36 degrees Fahrenheit to 46 degrees Fahrenheit (2 degrees Celsius to 8 degrees Celsius). Do not freeze.

The manufacturer's product information should be consulted for current reconstitution and dilution recommendations.