Glucarpidase Dosage
This dosage information may not include all the information needed to use Glucarpidase safely and effectively. See additional information for Glucarpidase.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Methotrexate Overdosage
50 mg/kg intravenously one time.
Usual Pediatric Dose for Methotrexate Overdosage
50 mg/kg intravenously one time.
Renal Dose Adjustments
No adjustment to the starting dose is needed for patients with preexisting mild and moderate renal impairment.
Liver Dose Adjustments
No specific studies of glucarpidase in patients with hepatic impairment have been conducted.
Dose Adjustments
No dosage adjustment is recommended based on gender, weight, or geriatric status.
Precautions
Serious allergic reactions (incidence greater than 1%), including anaphylactic reactions, may occur.
Do not administer leucovorin within 2 hours before or after a dose of glucarpidase.
Continue hydration and alkalinization of the urine as indicated.
Dialysis
Data not available.
Other Comments
Store glucarpidase at 36 degrees Fahrenheit to 46 degrees Fahrenheit (2 degrees Celsius to 8 degrees Celsius). Do not freeze.
The manufacturer's product information should be consulted for current reconstitution and dilution recommendations.
