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Glucarpidase Side Effects

Not all side effects for glucarpidase may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to glucarpidase: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by glucarpidase. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking glucarpidase, check with your doctor or nurse immediately:

Less common
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
  • Cough
  • difficulty with swallowing
  • dizziness
  • fever
  • headache
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • nervousness
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • redness of the skin
  • shortness of breath
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • wheezing

Some of the side effects that can occur with glucarpidase may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • feeling of warmth
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • vomiting
  • Diarrhea
  • shakiness in the legs, arms, hands, or feet
  • sore throat
  • trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to glucarpidase: intravenous powder for injection


The most common side effects reported were paresthesia, flushing, nausea and/or vomiting, hypotension, and headache.[Ref]


Very common (10% or more): Anti-glucarpidase antibodies (21%)[Ref]


Uncommon (0.1% to 1%): Hypersensitivity (including anaphylactic reactions)[Ref]


Common (1% to 10%): Flushing, hypotension
Uncommon (0.1% to 1%): Hypertension[Ref]


Uncommon (0.1% to 1%): Rash[Ref]


Common (1% to 10%): Nausea, vomiting
Uncommon (0.1% to 1%): Diarrhea[Ref]

Nervous system

Common (1% to 10%): Paresthesia, headache, burning sensation
Uncommon (0.1% to 1%): Tremor[Ref]


Uncommon (0.1% to 1%): Blurred vision[Ref]


Common (1% to 10%): Feeling hot[Ref]


Uncommon (0.1% to 1%): Throat irritation, throat tightness[Ref]


1. "Product Information. Voraxaze (glucarpidase)." BTG International Inc, West Conshohocken, PA.

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