Glucarpidase Side Effects

Not all side effects for glucarpidase may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to glucarpidase: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by glucarpidase. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking glucarpidase, check with your doctor or nurse immediately:

Less common
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
Rare
  • Cough
  • difficulty with swallowing
  • dizziness
  • fever
  • headache
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • nervousness
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • redness of the skin
  • shortness of breath
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • wheezing

Some of the side effects that can occur with glucarpidase may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • feeling of warmth
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • vomiting
Rare
  • Diarrhea
  • shakiness in the legs, arms, hands, or feet
  • sore throat
  • trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to glucarpidase: intravenous powder for injection

General

The most common side effects reported were paresthesia, flushing, nausea and/or vomiting, hypotension, and headache.

Immunologic

Very common (10% or more): Anti-glucarpidase antibodies (21%)

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity (including anaphylactic reactions)

Cardiovascular

Common (1% to 10%): Flushing, hypotension
Uncommon (0.1% to 1%): Hypertension

Dermatologic

Uncommon (0.1% to 1%): Rash

Gastrointestinal

Common (1% to 10%): Nausea, vomiting
Uncommon (0.1% to 1%): Diarrhea

Nervous system

Common (1% to 10%): Paresthesia, headache, burning sensation
Uncommon (0.1% to 1%): Tremor

Ocular

Uncommon (0.1% to 1%): Blurred vision

Other

Common (1% to 10%): Feeling hot

Respiratory

Uncommon (0.1% to 1%): Throat irritation, throat tightness

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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