Antizol

Generic Name: fomepizole (foe MEP i zole)
Brand Name: Antizol

What is Antizol (fomepizole)?

Fomepizole is an antidote to certain types of poison.

Fomepizole is used to treat poisoning with ethylene glycol (antifreeze) or methanol (contained in solvents, fuels, and other household or automotive chemicals). Fomepizole is sometimes used together with hemodialysis to rid the body of a poison.

Fomepizole may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Antizol (fomepizole)?

In a poisoning situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.

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What should I discuss with my health care provider before receiving Antizol (fomepizole)?

If possible before you receive fomepizole, tell your doctor if you have:

  • an allergy to any drug;

  • kidney disease or if you are unable to urinate; or

  • if you recently drank alcohol.

FDA pregnancy category C. It is not known whether fomepizole will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether fomepizole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In an emergency situation, it may not be possible before you are treated with fomepizole to tell your caregivers if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medicine.

How is fomepizole given?

Fomepizole is injected into a vein through an IV. A healthcare provider will give you this injection.

You may be given other medicines and IV fluids as part of your treatment.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving fomepizole. Your blood and urine will also need to be tested often during treatment, and your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

You will also be watched for any effects of the poisoning, such as problems with vision, breathing, or urination.

What happens if I miss a dose?

Because you will receive fomepizole in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Antizol (fomepizole)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Antizol (fomepizole) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness.

  • severe nausea, severe dizziness or spinning sensation; or

  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • headache;

  • dizziness, drowsiness;

  • nausea; or

  • unpleasant or metallic taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Antizol (fomepizole)?

Other drugs may interact with fomepizole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about fomepizole.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Revision Date: 2014-04-22, 12:54:13 PM.

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