This dosage information may not include all the information needed to use Fulvestrant safely and effectively. See additional information for Fulvestrant.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Breast Cancer
Initial dose: 500 mg IM on days 1, 15, and 29, then once a month thereafter.
Renal Dose Adjustments
CrCl 30 mL/min or more: No adjustment recommended
CrCl 29 mL/min or less: Data not available
Liver Dose Adjustments
Mild liver function (Child-Pugh class A): No specific dose adjustment guidelines have been suggested; however, caution is recommended.
Moderate liver dysfunction (Child-Pugh class B): 250 mg IM on days 1, 15, and 29, then once a month thereafter.
Severe liver dysfunction (Child-Pugh class C): Data not available
Women of childbearing age should be advised not to become pregnant while receiving fulvestrant.
Because fulvestrant is administered intramuscularly it should be used with caution in patients with bleeding diatheses, thrombocytopenia, or patients on anticoagulants.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Data not available
In patients with normal renal and hepatic function, fulvestrant should be administered as two 250 mg injections, one in each buttock, by slow intramuscular injection (1 to 2 minutes per injection).