Floxin Tablets Dosage
Generic name: ofloxacin
Dosage form: tablet, coated
This dosage information does not include all the information needed to use Floxin Tablets safely and effectively. See full prescribing information for Floxin Tablets.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
The usual dose of FLOXIN® (ofloxacin tablets) Tablets is 200 mg to 400 mg orally every 12 h as described in the following dosing chart. These recommendations apply to patients with normal renal function (i.e., creatinine clearance >50 mL/min). For patients with altered renal function (i.e., creatinine clearance ≤50 mL/min), see the Patients with Impaired Renal Function Subsection.
| Infection* | Unit Dose | Frequency | Duration | Daily Dose |
|---|---|---|---|---|
|
||||
| Acute Bacterial Exacerbation of Chronic Bronchitis | 400 mg | q12h | 10 days | 800 mg |
| Comm. Acquired Pneumonia | 400 mg | q12h | 10 days | 800 mg |
| Uncomplicated Skin and Skin Structure Infections | 400 mg | q12h | 10 days | 800 mg |
| Acute, Uncomplicated Urethral and Cervical Gonorrhea | 400 mg | single dose | 1 day | 400 mg |
| Nongonococcal Cervicitis/Urethritis due to C. trachomatis | 300 mg | q12h | 7 days | 600 mg |
| Mixed Infection of the urethra and cervix due to C. trachomatis and N. gonorrhoeae | 300 mg | q12h | 7 days | 600 mg |
| Acute Pelvic Inflammatory Disease | 400 mg | q12h | 10–14 days | 800 mg |
| Uncomplicated Cystitis due to E. coli or K. pneumoniae | 200 mg | q12h | 3 days | 400 mg |
| Uncomplicated Cystitis due to other approved pathogens | 200 mg | q12h | 7 days | 400 mg |
| Complicated UTI's | 200 mg | q12h | 10 days | 400 mg |
| Prostatitis due to E.Coli | 300 mg | q12h | 6 weeks | 600 mg |
Antacids containing calcium, magnesium, or aluminum; sucralfate; divalent or trivalent cations such as iron; or multivitamins containing zinc; or Videx® (didanosine) should not be taken within the two-hour period before or within the two-hour period after taking ofloxacin. (See PRECAUTIONS.)
Patients with Impaired Renal Function
Dosage should be adjusted for patients with a creatinine clearance ≤50 mL/min. After a normal initial dose, dosage should be adjusted as follows:
| Creatinine Clearance | Maintenance Dose | Frequency |
|---|---|---|
| 20–50 mL/min | the usual recommended unit dose | q24h |
| <20 mL/min | 1/2 the usual recommended unit dose | q24h |
When only the serum creatinine is known, the following formula may be used to estimate creatinine clearance.
| Men: Creatinine clearance (mL/min) = | Weight (kg) × (140-age) | |
| 72 × serum creatinine (mg/dL) | ||
| Women: 0.85 × the value calculated for men. | ||
The serum creatinine should represent a steady-state of renal function.
