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Ferriprox Oral Solution Dosage

Generic name: DEFERIPRONE 100mg in 1mL
Dosage form: oral solution
Drug classes: Antidotes, Chelating agents

Medically reviewed by Drugs.com. Last updated on Nov 20, 2023.

Important Dosage and Administration Information

​Monitoring for Safety

​Due to the risk of agranulocytosis, monitor ANC before and during FERRIPROX therapy.

​Test ANC prior to start of FERRIPROX therapy and monitor on the following schedule during treatment:

  • ​First six months of therapy: Monitor ANC weekly;
  • ​Next six months of therapy: Monitor ANC once every two weeks;
  • ​After one year of therapy: Monitor ANC every two to four weeks (or at the patient's blood transfusion interval in patients that have not experienced an interruption due to any decrease in ANC [see Warnings and Precautions (5.1)].

​Due to the risk of hepatic transaminase elevations, monitor ALT before and monthly during FERRIPROX therapy [see Warnings and Precautions (5.2)].

​Due to the risk of zinc deficiency, monitor zinc levels before and regularly during FERRIPROX therapy [see Warnings and Precautions (5.3)].

Recommended Dosage for FERRIPROX Oral Solution for Adult and Pediatric Patients with Transfusional Iron Overload due to Thalassemia Syndromes, Sickle Cell Disease or Other Anemias

Starting Dosage

The recommended starting oral dosage of FERRIPROX Oral Solution is 25 mg/kg (actual body weight), three times per day for a total of 75 mg/kg/day. Round dose to the nearest 2.5 mL.

Table 1: Volume of FERRIPROX Oral Solution in mL Needed to Achieve the Total Starting Daily Dosage of 75 mg/kg (rounded to the nearest 2.5 mL)
Body Weight
(kg)		 Morning Midday Evening
20 5 5 5
30 7.5 7.5 7.5
40 10 10 10
50 12.5 12.5 12.5
60 15 15 15
70 17.5 17.5 17.5
80 20 20 20
90 22.5 22.5 22.5

To minimize gastrointestinal upset when first starting therapy, dosing can start at 45 mg/kg/day and increase weekly by 15 mg/kg/day increments until the full prescribed dose is achieved.

Dosage Adjustments

Tailor dosage adjustments to the individual patient's response and therapeutic goals (maintenance or reduction of body iron burden). The maximum oral dosage is 33 mg/kg (actual body weight), three times per day for a total of 99 mg/kg/day.

Table 2: Volume of FERRIPROX Oral Solution in mL Needed to Achieve the Maximum Total Daily Dosage of 99 mg/kg (rouded to the nearest 2.5 mL)
Body Weight
(kg)		 Morning Midday Evening
20 7.5 5 7.5
30 10 10 10
40 15 10 15
50 17.5 15 17.5
60 20 20 20
70 25 22.5 22.5
80 27.5 25 27.5
90 30 30 30

Monitoring Ferritin Levels to Assess Efficacy

Monitor serum ferritin concentration every two to three months to assess the effect of FERRIPROX on body iron stores. If the serum ferritin is consistently below 500 mcg/L, consider temporarily interrupting FERRIPROX therapy until serum ferritin rises above 500 mcg/L.

Dosage Modification for Drug Interactions

Allow at least a 4-hour interval between administration of FERRIPROX and other drugs or supplements containing polyvalent cations such as iron, aluminum, or zinc [see Drug Interactions (7.2), Clinical Pharmacology (12.3)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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