Ferriprox Side Effects

Generic Name: deferiprone

Note: This page contains information about the side effects of deferiprone. Some of the dosage forms included on this document may not apply to the brand name Ferriprox.

Not all side effects for Ferriprox may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to deferiprone: oral tablet

Along with its needed effects, deferiprone (the active ingredient contained in Ferriprox) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking deferiprone:

More common
  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Fever with or without chills
  • general feeling of tiredness or weakness
  • hoarseness
Incidence not known
  • Abdominal or stomach pain
  • anxiety
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • blurred vision
  • chest pain or discomfort
  • clay-colored stools
  • confusion
  • convulsions
  • dark urine
  • decreased urination
  • dilated neck veins
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • extreme fatigue
  • fainting
  • fast or irregular heartbeat
  • headache
  • hives
  • increase in heart rate
  • increased sweating
  • irregular breathing
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle tremors
  • nausea
  • nervousness
  • painful knees and ankles
  • pinpoint red spots on the skin
  • pounding in the ears
  • raised red swellings on the skin, the buttocks, legs, or ankles
  • rapid weight gain
  • rapid, deep breathing
  • rapid, shallow breathing
  • rash
  • redness of the skin
  • restlessness
  • severe nausea or vomiting
  • slow heartbeat
  • sneezing
  • spots on your skin resembling a blister or pimple
  • stomach cramps
  • sudden shortness of breath or troubled breathing
  • sugar in the urine
  • sunken eyes
  • sweating
  • swelling around the eyes
  • swelling of the eyelids, face, lips, hands, or feet
  • thirst
  • tightness in the chest
  • tingling of the hands or feet
  • trouble with balance
  • troubled breathing or swallowing
  • unpleasant breath odor
  • unusual weight gain or loss
  • vision changes
  • vomiting of blood
  • weight gain
  • wheezing
  • wrinkled skin
  • yellow eyes or skin

Some side effects of deferiprone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach discomfort
  • difficulty with moving
  • muscle pain or stiffness
  • reddish or brow discoloration of the urine
Less common
  • Acid or sour stomach
  • back pain
  • belching
  • diarrhea
  • heartburn
  • increased or decreased appetite
  • indigestion
  • pain in the arms or legs
  • stomach upset
Incidence not known
  • Bloody nose
  • clenching, gnashing, or grinding teeth
  • constipation
  • coughing or spitting up blood
  • depression
  • difficulty opening the mouth
  • difficulty with speaking
  • drooling
  • hives or welts
  • impaired psychomotor skills
  • increased sensitivity of the skin to sunlight
  • lockjaw
  • loss of appetite
  • loss of balance control
  • muscle spasm, especially of the neck and back
  • muscle trembling, jerking, or stiffness
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • redness or other discoloration of the skin
  • restlessness
  • severe sunburn
  • shuffling walk
  • sleepiness or unusual drowsiness
  • stiffness of the limbs
  • stomach bloating, burning, cramping, or pain
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back

For Healthcare Professionals

Applies to deferiprone: oral tablet

Cardiovascular

Cardiovascular side effects have included postmarketing reports of atrial fibrillation, cardiac failure, hypotension and hypertension.

Dermatologic

Dermatologic side effects have included postmarketing reports of hyperhidrosis, periorbital edema, photosensitivity reaction, pruritus, urticarial, rash and Henoch-Schonlein purpura.

Gastrointestinal

Gastrointestinal side effects have included nausea (12.6%), abdominal pain/discomfort (10.4%), vomiting (9.8%), diarrhea (3%), dyspepsia (2%) and postmarketing reports of enterocolitis, rectal hemorrhage, gastric ulcer, pancreatitis, and parotid gland enlargement.

General

General side effects have included postmarketing reports of chills, pyrexia, edema peripheral, and multi-organ failure.

Genitourinary

Genitourinary side effects have included chromaturia (14.6%).

Hematologic

Hematologic side effects have included neutropenia (6.2%), agranulocytosis (1.7%), and postmarketing reports of thrombocytosis, and pancytopenia.

Hepatic

Hepatic side effects have included postmarketing reports of jaundice, and hepatomegaly.

Hypersensitivity

Hypersensitivity reactions have included postmarketing reports of anaphylactic shock, and hypersensitivity.

Immunologic

Immunologic side effects have included postmarketing reports of cryptococcal cutaneous infection, enteroviral encephalitis, pharyngitis, pneumonia, sepsis, furuncle, infectious hepatitis, rash pustular, and subcutaneous abscess.

Metabolic

Metabolic side effects have included weight increased (1.9%) and postmarketing reports of metabolic acidosis, and dehydration.

Laboratory abnormalities have included alanine aminotransferase (ALT) increased (7.5%), neutrophil count decreased (7.3%), and aspartate aminotransferase (AST) increased (1.2%) and postmarketing reports of blood bilirubin increased, and blood creatinine phosphokinase increased.

Musculoskeletal

Musculoskeletal side effects have included arthralgia (9.8%), back pain (2.0%), pain in extremity (1.9%), arthropathy (1.4%) and postmarketing reports of myositis, chondropathy, and trismus.

Nervous system

Nervous system side effects have included headache (2.5%) and postmarketing reports of cerebellar syndrome, cerebral hemorrhage, convulsion, gait disturbance, intracranial pressure increased, psychomotor skills impaired, pyramidal tract syndrome, and somnolence.

Ocular

Ocular side effects have included postmarketing reports of diplopia, papilledema, and retinal toxicity.

Other

Other side effects have included postmarketing reports of hypospadias.

Psychiatric

Psychiatric side effects have included postmarketing reports of bruxism, depression, obsessive-compulsive disorder.

Renal

Renal side effects have included postmarketing reports of glycosuria and hemoglobinuria.

Respiratory

Respiratory side effects have included postmarketing reports of acute respiratory distress syndrome, epistaxis, hemoptysis, and pulmonary embolism.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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