Amlodipine / Atorvastatin Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: Individualize based on the effectiveness and tolerance for each individual component. Generally the initial starting dose for each component is amlodipine 5 mg orally once a day and atorvastatin 10, 20, or 40 mg orally once a day.

Maintenance dose: amlodipine 5 mg to 10 mg orally once a day, and atorvastatin 10 mg to 80 mg once a day.

Usual Adult Dose for Angina Pectoris

Initial dose: Individualize based on the effectiveness and tolerance for each individual component. Generally the initial starting dose for each component is amlodipine 5 mg orally once a day and atorvastatin 10, 20, or 40 mg orally once a day.

Maintenance dose: amlodipine 5 mg to 10 mg orally once a day, and atorvastatin 10 mg to 80 mg once a day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Atorvastatin is contraindicated in patients with active liver disease or with unexplained elevations in liver function tests.

Dose Adjustments

In general, titration of amlodipine should proceed over 7 to 14 days.

Studies in elderly patients have shown decreased clearance of amlodipine with a resulting increase in AUC of approximately 40 to 60%; therefore, a lower initial dose of amlodipine may be required. Plasma concentrations of atorvastatin are higher (approximately 40% for Cmax and 30% for AUC) in healthy elderly subjects (age greater than or equal to 65 years) than in young adults. Clinical data suggest a greater degree of LDL-lowering at any dose of atorvastatin in the elderly population compared to younger adults.

In patients taking the HIV protease inhibitor nelfinavir or the hepatitis C protease inhibitor boceprevir, the dose of atorvastatin should not exceed 40 mg and monitoring is recommended.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Amlodipine is not removed by hemo- or peritoneal dialysis.

Other Comments

Cholesterol levels should be monitored periodically with consideration given to reducing the dosage if cholesterol levels fall significantly below the targeted range.

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