Skip to Content

Amlodipine / atorvastatin Side Effects

Not all side effects for amlodipine / atorvastatin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amlodipine / atorvastatin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by amlodipine / atorvastatin. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amlodipine / atorvastatin:

More common
  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
  • Chest pain or discomfort
  • dilated neck veins
  • extra heartbeats
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • pulse irregularity
  • swelling of the face, fingers, feet, or lower legs
  • weight gain
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chills
  • dark-colored urine
  • diarrhea
  • fever
  • joint or muscle pain
  • muscle cramps or spasms
  • muscle stiffness
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips

If any of the following symptoms of overdose occur while taking amlodipine / atorvastatin, get emergency help immediately:

Symptoms of overdose
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • sweating

Some of the side effects that can occur with amlodipine / atorvastatin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Body aches or pain
  • congestion
  • difficulty with moving
  • headache
  • lower back or side pain
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • runny or stuffy nose
  • tender, swollen glands in the neck
  • voice changes
Less common
  • Accidental injury
  • acid or sour stomach
  • belching
  • bloated or full feeling
  • difficulty having a bowel movement (stool)
  • excess air or gas in the stomach or intestines
  • general feeling of discomfort or illness
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • nausea
  • passing gas
  • shivering
  • sleepiness or unusual drowsiness
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • vomiting
  • Anxiety
  • bad, unusual, or unpleasant (after) taste
  • blistering, crusting, irritation, itching, or reddening of the skin
  • burning feeling in the chest or stomach
  • burning while urinating
  • change in near or distance vision
  • change in taste
  • change in the color of the skin
  • cold and clammy skin
  • cracked, dry, scaly skin
  • difficulty in focusing eyes
  • dry mouth
  • dryness of the eyes
  • excessive muscle tone
  • frequent urination
  • hair loss or thinning of the hair
  • increased appetite
  • increased volume of pale, dilute urine
  • irritability
  • lack of feeling or emotion
  • loose stools
  • loss of memory
  • muscle tension or tightness
  • muscle weakness
  • problems with memory
  • restlessness
  • severe and throbbing headache
  • shakiness and unsteady walk
  • sneezing
  • tenderness in the stomach area
  • transient, mild, or pleasant aromatic odor
  • trembling, or other problems with muscle control or coordination
  • twitching
  • uncaring
  • unsteadiness
  • welts

For Healthcare Professionals

Applies to amlodipine / atorvastatin: oral tablet


The most common side effect of amlodipine was edema. The most common side effects of atorvastatin were diarrhea, nasopharyngitis, and arthralgia.[Ref]


Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea
Uncommon (0.1% to 1%): Flatulence

Common (1% to 10%): Nausea, abdominal pain, constipation, dyspepsia
Uncommon (0.1% to 1%): Dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia, dry mouth, flatulence, altered bowel habits
Frequency not reported: Gastritis, loose stools

Very common (10% or more): Diarrhea (up to 14.1%)
Common (1% to 10%): Dyspepsia, nausea, abdominal pain, constipation, flatulence
Uncommon (0.1% to 1%): Abdominal discomfort, vomiting
Rare (less than 0.1%): Eructation[Ref]


Common (1% to 10%): Respiratory tract infection
Uncommon (0.1% to 1%): Pharyngitis, rhinitis

Common (1% to 10%): Epistaxis, respiratory tract infection
Uncommon (0.1% to 1%): Dyspnea, pharyngitis, rhinitis
Frequency not reported: Coughing

Very common (10% or more): Nasopharyngitis (up to 12.9%)
Common (1% to 10%): Pharyngolaryngeal pain, respiratory tract infection, rhinitis
Uncommon (0.1% to 1%): Pharyngitis, asthma
Rare (less than 0.1%): Sinusitis
Frequency not reported: Epistaxis, interstitial lung disease[Ref]


Common (1% to 10%): Back pain, arthralgia, myalgia
Uncommon (0.1% to 1%): Leg cramps

Common (1% to 10%): Back pain, myalgia, arthralgia
Uncommon (0.1% to 1%): Arthrosis, muscle cramps, leg cramps
Frequency not reported: Muscle weakness, twitching

Very common (10% or more): Arthralgia (up to 11.7%)
Common (1% to 10%): Pain in extremity, musculoskeletal pain, muscle spasms, myalgia, back pain
Uncommon (0.1% to 1%): Creatine kinase elevations 10 times the upper limit of normal or greater, leg cramps, neck pain
Rare (less than 0.1%): Myositis, myopathy, muscle fatigue
Frequency not reported: Joint swelling, blood creatine phosphokinase increased
Postmarketing reports: Rhabdomyolysis, tendon rupture, immune-mediated necrotizing myopathy[Ref]


Common (1% to 10%): Accidental injury, asthenia, pain
Uncommon (0.1% to 1%): Vertigo

Very common (10% or more): Edema (up to 10.8%)
Common (1% to 10%): Fatigue, accidental injury, asthenia, pain
Uncommon (0.1% to 1%): Vertigo, malaise, rigors, tinnitus, gynecomastia

Common (1% to 10%): Accidental injury, asthenia
Uncommon (0.1% to 1%): Pain, vertigo, deafness, malaise
Rare (less than 0.1%): Tinnitus, pyrexia
Postmarketing reports: Fatigue, gynecomastia[Ref]


Common (1% to 10%): Palpitation, vasodilation, peripheral edema
Uncommon (0.1% to 1%): Hypertension

Common (1% to 10%): Flushing, palpitation, peripheral edema
Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, vasodilation, hypotension, postural hypotension
Frequency not reported: Cardiac failure, pulse irregularity, extrasystoles, myocardial infarction

Common (1% to 10%): Hypertension, palpitation
Uncommon (0.1% to 1%): Vasodilation
Postmarketing reports: Chest pain, peripheral edema[Ref]


Common (1% to 10%): GGT increased, ALT increased, AST increased

Uncommon (0.1% to 1%): GGT increased, ALT increased, AST increased, pancreatitis
Postmarketing reports: Jaundice, hepatic enzyme elevations, hepatitis

Common (1% to 10%): Transaminase elevations 3 times the upper limit of normal or greater twice within 4 to 10 days
Uncommon (0.1% to 1%): GGT increased, ALT increased, AST increased
Rare (less than 0.1%): Pancreatitis, hepatitis, cholestasis
Frequency not reported: Transaminases increased, liver function test abnormal, blood alkaline phosphatase increased
Postmarketing reports: Fatal and non-fatal hepatic failure[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Paresthesia

Common (1% to 10%): Dizziness, somnolence, headache
Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paresthesia, tremor, postural dizziness
Frequency not reported: Ataxia, hypertonia, migraine, amnesia, parosmia, taste perversion
Postmarketing reports: Extrapyramidal disorder

Common (1% to 10%): Hemorrhagic stroke, headache, dizziness
Uncommon (0.1% to 1%): Hypoesthesia, paresthesia
Rare (less than 0.1%): Peripheral neuropathy
Postmarketing reports: Cognitive impairment, amnesia, dysgeusia[Ref]


Common (1% to 10%): Flu syndrome
Uncommon (0.1% to 1%): Allergic reaction

Common (1% to 10%): Allergic reaction
Uncommon (0.1% to 1%): Flu syndrome

Common (1% to 10%): Flu syndrome
Uncommon (0.1% to 1%): Allergic reaction, infection, influenza
Rare (less than 0.1%): Hypersensitivity, anaphylaxis[Ref]


Common (1% to 10%): Rash

Common (1% to 10%): Rash, rash erythematous
Uncommon (0.1% to 1%): Angioedema, erythema multiforme, pruritus, rash maculopapular, sweating increased, purpura, alopecia
Frequency not reported: Skin discoloration, urticaria, skin dryness, dermatitis, cold and clammy skin

Uncommon (0.1% to 1%): Rash, pruritus, urticaria
Rare (less than 0.1%): Angioedema, alopecia
Postmarketing reports: Angioneurotic edema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Uncommon (0.1% to 1%): Depression, insomnia

Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes
Frequency not reported: Apathy, agitation

Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Depression, nightmare[Ref]


Uncommon (0.1% to 1%): Urinary frequency

Common (1% to 10%): Male sexual dysfunction, urinary frequency
Uncommon (0.1% to 1%): Female sexual dysfunction, micturition frequency, micturition disorder, nocturia
Frequency not reported: Dysuria, polyuria

Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Urinary frequency, erectile dysfunction
Rare (less than 0.1%): White blood cells urine positive[Ref]


Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst
Frequency not reported: Increased appetite

Common (1% to 10%): Diabetes
Uncommon (0.1% to 1%): Anorexia
Rare (less than 0.1%): Hypoglycemia
Frequency not reported: Hyperglycemia
Postmarketing reports: Weight increased[Ref]


Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain
Frequency not reported: Abnormal visual accommodation, xerophthalmia

Uncommon (0.1% to 1%): Vision blurred[Ref]


Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Postmarketing reports: Thrombocytopenia[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Caduet (amlodipine-atorvastatin)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.