Amitiza Dosage
Generic name: lubiprostone
Dosage form: capsule, gelatin coated
This dosage information does not include all the information needed to use Amitiza safely and effectively. See full prescribing information for Amitiza.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
​Amitiza should be taken orally with food and water. Physicians and patients should periodically assess the need for continued therapy.
Chronic Idiopathic Constipation
The recommended dose is 24 mcg twice daily orally with food and water.
Reduced dosage in patients with hepatic impairment
For patients with moderately impaired hepatic function (Child-Pugh Class B), the recommended dose is 16 mcg twice daily. For patients with severely impaired hepatic function (Child-Pugh Class C), the recommended dose is 8 mcg twice daily. If this dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response.
Irritable Bowel Syndrome with Constipation
The recommended dose is 8 mcg twice daily orally with food and water.
Reduced dosage in patients with severe hepatic impairment
For patients with severely impaired hepatic function (Child-Pugh Class C), the recommended dose is 8 mcg once daily. If this dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response. Dosage adjustment is not required for patients with moderately impaired hepatic function (Child-Pugh Class B).
