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Alprazolam Dosage

Applies to the following strength(s): 0.25 mg ; 0.5 mg ; 1 mg ; 2 mg ; 3 mg ; 0.5 mg/5 mL ; 1 mg/mL

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Anxiety

Immediate-release tablets/disintegrating tablets:
0.25 to 0.5 mg orally administered 3 times a day
Maximum dose: 4 mg orally administered in divided doses

Comments:
-The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
-Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.
-The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction.
-Patients who are currently being treated with divided doses of immediate-release tablets, for example 3 to 4 times a day, may be switched to extended-release tablets at the same total daily dose taken once a day.
-The dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day.
-The times of administration should be distributed as evenly as possible throughout the waking hours

Uses:
-Management of anxiety disorder
-Short-term relief of symptoms of anxiety

Usual Adult Dose for Panic Disorder

Immediate-release tablets/ disintegrating tablets:
0.5 mg orally administered 3 times a day
Maximum dose: 10 mg orally per day

Extended-release tablets:
Initial dose: 0.5 to 1 mg orally once a day
Maintenance dose: 3 to 6 mg orally per day, preferably in the morning
Maximum dose: 10 mg orally per day

Comments:
-The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
-Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.
-The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction.
-Patients who are currently being treated with divided doses of immediate-release tablets, for example 3 to 4 times a day, may be switched to extended-release tablets at the same total daily dose taken once a day.
-The dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day.
-The times of administration should be distributed as evenly as possible throughout the waking hours

Use: Treatment of panic disorder, with or without agoraphobia

Usual Geriatric Dose for Anxiety

Elderly or debilitated patients:
Immediate-release tablets/ disintegrating tablets:
0.25 mg orally administered 2 or 3 times a day

Comments:
-If side effects develop, the dose may be lowered.
-The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
-Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Uses:
-Management of anxiety disorder
-Short-term relief of symptoms of anxiety

Usual Geriatric Dose for Panic Disorder

Elderly or debilitated patients:
Extended-release tablets:
0.5 mg orally once a day

Comments:
-If side effects develop, the dose may be lowered.
-The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
-Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.
-Patients who are currently being treated with divided doses of immediate-release tablets, for example 3 to 4 times a day, may be switched to extended-release tablets at the same total daily dose taken once a day.

Use: Treatment of panic disorder, with or without agoraphobia

Renal Dose Adjustments

-Impaired renal function: Use with caution

Liver Dose Adjustments

Immediate-release tablets/ disintegrating tablets:
-Mild to moderate hepatic impairment: Use with caution
-Severe hepatic impairment: 0.25 mg orally administered 2 or 3 times a day

Extended-release tablets:
-Mild to moderate hepatic impairment: Use with caution
-Severe hepatic impairment: 0.5 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:
-Tablets should not be chewed, crushed, or broken.
-Orally disintegrating tablets should be placed on top of the tongue.

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