Alendronate Dosage

This dosage information may not include all the information needed to use Alendronate safely and effectively. See additional information for Alendronate.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Osteoporosis

70 mg orally once weekly (tablet, oral solution, or effervescent tablet) or 10 mg orally once daily.


For glucocorticoid-induced osteoporosis: 5 mg once daily or 10 mg once daily for postmenopausal women not receiving estrogen.

Usual Adult Dose for Paget's Disease

40 mg orally once a day.

Therapy for Paget's disease should continue for 6 months and may need to be repeated for another 6 months if relapse occurs.

Usual Adult Dose for Prevention of Osteoporosis

5 mg orally once daily or 35 mg orally once weekly.

Renal Dose Adjustments

No dosage adjustment is recommended for patients with mild to moderate renal insufficiency (creatinine clearance 35 to 60 mL/min). Alendronate is not recommended for patients with a CrCl less than 35 mL/min.

Liver Dose Adjustments

No adjustment recommended.

Dose Adjustments

No dosage adjustment is recommended for the elderly

Precautions

Alendronate is not recommended for patients with a CrCl less than 35 mL/min. Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Administration advice:
-Take at least 30 minutes before the first food, beverage, or medication of the day.
-Swallow tablets with a full glass (6 to 8 ounces) of plain water.
-Follow oral solution with at least 2 ounces (approximately 1/4 cup) of plain water.
-Dissolve effervescent tablets in 4 ounces of room temperature plain water. After effervescence stops, wait 5 minutes, then stir solution for 10 seconds, and ingest.
-Do not lie down for at least 30 minutes after taking and until the first food of the day.
-Wait 30 minutes after taking before eating, drinking (anything but plain water), or taking other medications or supplements.
-Do not take at bedtime.

General:
-Supplemental calcium and vitamin D may be necessary if dietary intake is inadequate.

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