Adapalene Topical Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Acne

Adapalene Topical 0.1% cream, 0.1% gel, 0.3% gel:
Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes.

Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne

Adapalene Topical 0.1% cream, 0.1% gel, 0.3% gel:

11 years or less: Safety and efficacy have not been established.

12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes.

Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Adapalene should not be applied to skin with cuts, abrasions, eczema, or sunburn.

Patients should minimize exposure to sunlight, including sunlamps, and use sunscreens and other protection whenever prolonged exposure is unavoidable. Therapy should be discontinued if sunburn develops, and not resumed until the skin fully recovers. Patients may also have a heightened susceptibility to irritation due to weather extremes (wind or cold).

Adapalene may cause erythema, dryness, scaling, burning, and itching, which usually begin the first 2 to 4 weeks of therapy but diminish with continued use. Patients who develop excessive irritation should use the medication less frequently, interrupt treatment briefly, or discontinue use totally.

Adapalene therapy may render the skin more vulnerable to the irritating effects of astringents, abrasive soaps, skin cleansers, and other facial chemicals and cosmetics that contain alcohol or have a strong drying effect. Concomitant use of these agents with adapalene should be approached with caution. Products containing alpha hydroxy or glycolic acids should be avoided.

Adapalene should not be used around the eyes, mouth, angles of the nose, mucous membranes, or on cut, abraded, or eczematous skin. Contact with the eye may cause an ocular reaction such as swelling, conjunctivitis, and irritation.

Wax epilation should not be performed on adapalene-treated skin.

Safety and effectiveness in pediatric patients under the age of 12 years has not been established.

Dialysis

Data not available

Other Comments

Initially, an apparent exacerbation of acne may appear within the first few weeks of treatment due to the action of adapalene topical on previously unseen lesions. Therapeutic results are typically noticed after 8 to 12 weeks of treatment.

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