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Viloxazine Disease Interactions

There are 4 disease interactions with viloxazine.

Moderate

Antidepressants (applies to viloxazine) mania

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bipolar Disorder

All antidepressants may occasionally cause mania or hypomania, particularly in patients with bipolar disorder. Therapy with antidepressants should be administered cautiously in patients with a history of mania/hypomania.

References

  1. (2001) "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories
  2. (2001) "Product Information. Desyrel (trazodone)." Bristol-Myers Squibb
  3. (2001) "Product Information. Serzone (nefazodone)." Bristol-Myers Squibb
  4. (2001) "Product Information. Remeron (mirtazapine)." Organon
  5. (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
  6. (2023) "Product Information. Exxua (gepirone)." Mission Pharmacal Company, 1
View all 6 references
Moderate

Viloxazine (applies to viloxazine) depression

Moderate Potential Hazard, Moderate plausibility.

Patients being treated with viloxazine should be monitored for clinical worsening and emergence of suicidal thoughts and behaviors. In clinical trials, higher rates of suicidal thoughts and behavior were reported in pediatric patients with attention deficit hyperactivity disorder (ADHD) receiving this drug than placebo. Prior to initiating treatment, patients should be screened for a personal or family history of suicide, bipolar disorder, and depression.

References

  1. (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
Moderate

Viloxazine (applies to viloxazine) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The effect of hepatic impairment on the pharmacokinetics of viloxazine is unknown. Viloxazine is not recommended in patients with hepatic impairment.

References

  1. (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
Moderate

Viloxazine (applies to viloxazine) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The exposure of viloxazine increases in patients with renal impairment. Dose reduction is recommended in patients with severe renal impairment (estimated glomerular filtration rate less than 30 mL/min/1.73 m3).

References

  1. (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc

Viloxazine drug interactions

There are 269 drug interactions with viloxazine.

Viloxazine alcohol/food interactions

There is 1 alcohol/food interaction with viloxazine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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