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Thiola Disease Interactions

There are 2 disease interactions with Thiola (tiopronin).

Moderate

Tiopronin (applies to Thiola) liver disease

Moderate Potential Hazard, Moderate plausibility.

The use of tiopronin has been associated with jaundice and abnormal liver function tests. Therapy with tiopronin should be administered cautiously in patients with a history of liver disease. Monitoring liver function tests is recommended.

References

  1. (2001) "Product Information. Thiola (tiopronin)." Mission Pharmacal Company
Moderate

Tiopronin (applies to Thiola) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Proteinuria, including nephrotic syndrome, and membranous nephropathy, have been reported with tiopronin use. Pediatric patients receiving greater than 50 mg/kg of tiopronin per day may be at increased risk for proteinuria. It is recommended to use caution when using this agent in patients with renal disease. Monitor patients for the development of proteinuria and discontinue therapy in patients who develop proteinuria.

References

  1. (2001) "Product Information. Thiola (tiopronin)." Mission Pharmacal Company

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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