Thiola Side Effects

Please note - some side effects for Thiola may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Thiola - for the Consumer

Thiola

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Thiola:

Appetite loss; changes in taste; diarrhea; drying of skin; gas; loss of appetite; nausea; soft stools; stomach bloating; stomach pain; vomiting; wrinkling or crumbling of skin.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; joint pain; muscle weakness; red rash with fever; sore throat; unusual bleeding or bruising; yellowing of skin or eyes.

Side Effects by Body System

Hepatic

Hepatic side effects have included jaundice and abnormal liver function tests.

Hypersensitivity

Hypersensitivity side effects have included fever, rash (erythematous, maculopapular, or morbilliform), and pruritus. Laryngeal edema, dyspnea, respiratory distress, chills, arthralgia, weakness and adenopathy have also been reported.

Patients experiencing immediate hypersensitivity reactions can be treated with antihistamines and tiopronin treatment restarted at a lower dose. Those experiencing a rash later in treatment (at least 6 months into therapy) usually cannot be restarted on tiopronin.

Immunologic

Immunologic side effects have included a simulated lupus erythematous occasionally associated with a positive antinuclear antibody test.

Gastrointestinal

Gastrointestinal side effects have included hypogeusia. Nausea, emesis, diarrhea or soft stools, anorexia, abdominal pain, and bloating or flatulence have also been reported.

Metabolic

Metabolic side effects have rarely included vitamin B6 deficiency.

Dermatologic

Dermatologic side effects have included wrinkling and friability of the skin. Ecchymosis, urticaria, warts, pemphigus, and elastosis perforans serpiginosa have also been reported.

Hematologic

Hematological side effects have included increased bleeding, anemia, leukopenia, thrombocytopenia, and eosinophilia.

Renal

Renal side effects have included proteinuria, nephrotic syndrome, and hematuria.

Respiratory

Respiratory side effects have included pharyngitis, bronchiolitis, hemoptysis, and pulmonary infiltrates.

Nervous system

Nervous system side effects have included myasthenic syndrome.

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