Tiopronin Pregnancy and Breastfeeding Warnings

Tiopronin is also known as: Thiola

Tiopronin Pregnancy Warnings

Tiopronin has been assigned to pregnancy category C by the FDA. Although animal studies have failed to reveal evidence of teratogenicity at doses up to 10 times the maximum recommended human dose, d-penicillamine has been shown to cause skeletal defects and cleft palate in animals at 10 times the human dose. Because these drugs are closely related, a similar teratogenicity might be expected for tiopronin. There are no controlled data in human pregnancy. Tiopronin is only recommended for use during pregnancy when benefit outweighs risk.

Tiopronin Breastfeeding Warnings

There are no data on the excretion of tiopronin into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, mothers taking tiopronin should not nurse their infants.

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