Zelnorm (tegaserod) Disease Interactions
There are 4 disease interactions with Zelnorm (tegaserod):
Tegaserod (Includes Zelnorm) ↔ Intestinal Obstruction
Severe Potential Hazard, High plausibility
Applies to: Intestinal Obstruction, Abdominal Adhesions, Gallbladder Disease
The use of tegaserod is contraindicated in patients with a history of bowel obstruction, symptomatic gallbladder disease, suspected sphincter of Oddi dysfunction, or abdominal adhesions. Stimulation of gastrointestinal motility might be harmful in these conditions.
Tegaserod (Includes Zelnorm) ↔ Liver Disease
Severe Potential Hazard, High plausibility
Applies to: Liver Disease
The use of tegaserod is contraindicated in patients with moderate or severe hepatic impairment, as it has not been adequately studied for treatment in this population. In subjects with mild hepatic impairment, mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of tegaserod were 16% and 31% higher, respectively, compared to subjects with normal hepatic function. No dosage adjustment is required in patients with mild hepatic impairment; however, caution is advised when using tegaserod in such patients.
Tegaserod (Includes Zelnorm) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
The use of tegaserod is contraindicated in patients with severely impaired renal function. According to the manufacturer, no change in the pharmacokinetics of tegaserod was observed in subjects with severe renal impairment requiring hemodialysis (CrCl < 15 mL/min/1.73 m2). However, the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of the main pharmacologically inactive metabolite of tegaserod increased 2- and 10-fold, respectively, compared to healthy controls. The clinical significance of this observation is unknown. No dosage adjustment is required in patients with mild to moderate renal impairment.
Tegaserod (Includes Zelnorm) ↔ Diarrhea
Moderate Potential Hazard, High plausibility
Applies to: Diarrhea
Tegaserod should not be initiated in patients who are experiencing or frequently experience diarrhea. Tegaserod stimulates gastrointestinal motility and may cause diarrhea, usually within the first week of treatment. Patients should contact their physician if they experience severe diarrhea during therapy, or if the diarrhea is accompanied by severe cramping, abdominal pain, or dizziness.
You should also know about...
Zelnorm (tegaserod) drug Interactions
There are 12 drug interactions with Zelnorm (tegaserod)
Zelnorm (tegaserod) alcohol/food Interactions
There is 1 alcohol/food interaction with Zelnorm (tegaserod)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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