Zantac 75 (ranitidine) Disease Interactions
There are 5 disease interactions with Zantac 75 (ranitidine):
Ranitidine (Includes Zantac 75) ↔ Porphyria
Severe Potential Hazard, Moderate plausibility
Applies to: Porphyria
Ranitidine may rarely precipitate acute porphyria attacks and should be avoided in patients with a history of acute porphyria.
Ranitidine (Includes Zantac 75) ↔ Hemodialysis
Moderate Potential Hazard, High plausibility
Applies to: hemodialysis
Ranitidine is partially removed by hemodialysis and should be administered after dialysis.
Ranitidine (Includes Zantac 75) ↔ Liver Disease
Moderate Potential Hazard, Low plausibility
Applies to: Liver Disease
Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.
Ranitidine (Includes Zantac 75) ↔ Pku
Moderate Potential Hazard, High plausibility
Applies to: Phenylketonuria
Zantac (brand of ranitidine) 150 EFFERdose tablets and granules both contain 16.84 mg of phenylalanine per each 150 mg of ranitidine. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).
Ranitidine (Includes Zantac 75) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.
You should also know about...
Zantac 75 (ranitidine) drug Interactions
There are 251 drug interactions with Zantac 75 (ranitidine)
Zantac 75 (ranitidine) alcohol/food Interactions
There is 1 alcohol/food interaction with Zantac 75 (ranitidine)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2012 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
