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Pralidoxime Disease Interactions

There are 2 disease interactions with pralidoxime.

Major

Pralidoxime (applies to pralidoxime) myasthenic crisis

Major Potential Hazard, High plausibility. Applicable conditions: Myasthenia Gravis

Pralidoxime reactivates cholinesterase activity resulting in reduced levels of acetylcholine and increased neuromuscular junction activity. Treatment of organophosphate poisoning in patients myasthenia gravis with pralidoxime can precipitate a myasthenic crisis.

References

  1. (2001) "Product Information. Protopam Chloride (pralidoxime)." Baxter Healthcare Corporation
Moderate

Pralidoxime (applies to pralidoxime) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Pralidoxime is eliminated by the kidney. Approximately 80% to 90% of pralidoxime is excreted in the urine as unchanged drug. The serum concentration of pralidoxime is increased in patients with renal impairment. Therapy with pralidoxime should be administered cautiously and dosages reduced in patients with compromised renal function. Clinical monitoring of renal function and muscular activity is recommended.

References

  1. (2001) "Product Information. Protopam Chloride (pralidoxime)." Baxter Healthcare Corporation

Pralidoxime drug interactions

There are 3 drug interactions with pralidoxime.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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