Pralidoxime Side Effects

Brand Names: Protopam Chloride

Please note - some side effects for Pralidoxime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

General

Many of the signs and symptoms of organophosphate poisoning are similar to the side effects of pralidoxime. It may be difficult to ascertain which effects are due to the drug and which are toxic symptoms.

Cardiovascular

Cardiovascular side effects have included tachycardia and increased systolic and diastolic blood pressure in normal subjects. Tachycardia has also occurred after excessively rapid infusions. Asystole and cardiac arrest have been reported; however, causality is unclear due to the presence of atropine and an organophosphate insecticide.

Musculoskeletal

Musculoskeletal side effects have included muscle weakness in normal subjects. Laryngospasm and muscle rigidity have occurred after excessively rapid infusions.

Nervous system

Nervous system side effects have included dizziness, headache, and drowsiness in normal subjects.

Respiratory

Respiratory side effects have included hyperventilation in normal subjects.

Ocular

Ocular side effects have included blurry vision, diplopia, and impaired accommodation in normal subjects.

Gastrointestinal

Gastrointestinal side effects have included nausea in normal subjects.

Hepatic

Hepatic side effects in normal subjects have frequently included transient elevations of creatine phosphokinase and occasional increases in AST and ALT, which return to normal within 2 weeks.

Local

Local side effects have included mild to moderate injection side pain within 40 to 60 minutes after intramuscular injection.

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