Drug Information
Side Effects > Pralidoxime

Pralidoxime Side Effects

Brand Names: Protopam Chloride

Please note - some side effects for Pralidoxime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).



Side Effects by Body System

General

Many of the signs and symptoms of organophosphate poisoning are similar to the side effects of pralidoxime. It may be difficult to ascertain which effects are due to the drug and which are toxic symptoms.

Cardiovascular

Cardiovascular side effects have included tachycardia and increased systolic and diastolic blood pressure in normal subjects. Tachycardia has also occurred after excessively rapid infusions. Asystole and cardiac arrest have been reported; however, causality is unclear due to the presence of atropine and an organophosphate insecticide.

Musculoskeletal

Musculoskeletal side effects have included muscle weakness in normal subjects. Laryngospasm and muscle rigidity have occurred after excessively rapid infusions.

Nervous system

Nervous system side effects have included dizziness, headache, and drowsiness in normal subjects.

Respiratory

Respiratory side effects have included hyperventilation in normal subjects.

Ocular

Ocular side effects have included blurry vision, diplopia, and impaired accommodation in normal subjects.

Gastrointestinal

Gastrointestinal side effects have included nausea in normal subjects.

Hepatic

Hepatic side effects in normal subjects have frequently included transient elevations of creatine phosphokinase and occasional increases in AST and ALT, which return to normal within 2 weeks.

Local

Local side effects have included mild to moderate injection side pain within 40 to 60 minutes after intramuscular injection.

Top

More resources:

Cerner Multum Protopam Chloride

Micromedex Pralidoxime - Includes detailed dosage instructions.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.


MedNotes
Advertisement

(web1)