Pralidoxime Side Effects
Some side effects of pralidoxime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to pralidoxime: injection injectable, injection powder for solution
Along with its needed effects, pralidoxime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking pralidoxime:More common
- Blurred or double vision
- change in near or distance vision
- difficult or rapid breathing
- difficulty in focusing the eyes
- difficulty with speaking
- fast, pounding, or irregular heartbeat or pulse
- muscle stiffness or weakness
- pain at the injection site (after injection into a muscle)
- Deep or fast breathing with dizziness
- numbness of the feet, hands, and around the mouth
Some side effects of pralidoxime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
For Healthcare Professionals
Applies to pralidoxime: intravenous powder for injection
Pralidoxime has been well tolerated in most cases; however, it should be considered that the desperate condition of the organophosphate-poisoned patient generally masks the minor signs and symptoms noted in normal subjects who have not been exposed to anticholinesterase poisons. Many of the signs and symptoms of organophosphate poisoning are similar to the side effects of pralidoxime. It may be difficult to ascertain which effects are due to the drug and which are toxic symptoms produced by atropine or the organophosphate compounds.
Cardiovascular side effects have included tachycardia and increased systolic and diastolic blood pressure in normal subjects. Tachycardia has also occurred after excessively rapid infusions. Asystole and cardiac arrest have been reported; however, causality is unclear due to the presence of atropine and an organophosphate insecticide.
Musculoskeletal side effects have included muscle weakness in normal subjects. Laryngospasm and muscle rigidity have occurred after excessively rapid infusions.
Nervous system side effects have included dizziness, headache, and drowsiness in normal subjects.
Respiratory side effects have included hyperventilation in normal subjects.
Ocular side effects have included blurred vision, diplopia, and impaired accommodation in normal subjects.
Gastrointestinal side effects have included nausea in normal subjects.
Metabolic side effects have included transient elevations of creatine phosphokinase in all normal subjects.
Hepatic side effects have included elevations of AST and/or ALT in normal subjects.
Elevated AST and/or ALT were reported in 1 of 6 normal subjects given 1200 mg intramuscularly and 4 of 6 normal subjects given 1800 mg intramuscularly. Levels returned to normal in about 2 weeks.
Local side effects have included mild to moderate injection site pain, 40 to 60 minutes after intramuscular injection.
More pralidoxime resources
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