Pralidoxime Side Effects

Please note - some side effects for Pralidoxime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

General

Pralidoxime has been well tolerated in most cases; however, it should be considered that the desperate condition of the organophosphate-poisoned patient generally masks the minor signs and symptoms noted in normal subjects who have not been exposed to anticholinesterase poisons. Many of the signs and symptoms of organophosphate poisoning are similar to the side effects of pralidoxime. It may be difficult to ascertain which effects are due to the drug and which are toxic symptoms produced by atropine or the organophosphate compounds.

Cardiovascular

Cardiovascular side effects have included tachycardia and increased systolic and diastolic blood pressure in normal subjects. Tachycardia has also occurred after excessively rapid infusions. Asystole and cardiac arrest have been reported; however, causality is unclear due to the presence of atropine and an organophosphate insecticide.

Musculoskeletal

Musculoskeletal side effects have included muscle weakness in normal subjects. Laryngospasm and muscle rigidity have occurred after excessively rapid infusions.

Nervous system

Nervous system side effects have included dizziness, headache, and drowsiness in normal subjects.

Respiratory

Respiratory side effects have included hyperventilation in normal subjects.

Ocular

Ocular side effects have included blurred vision, diplopia, and impaired accommodation in normal subjects.

Gastrointestinal

Gastrointestinal side effects have included nausea in normal subjects.

Metabolic

Metabolic side effects have included transient elevations of creatine phosphokinase in all normal subjects.

Hepatic

Hepatic side effects have included elevations of AST and/or ALT in normal subjects.

Elevated AST and/or ALT were reported in 1 of 6 normal subjects given 1200 mg intramuscularly and 4 of 6 normal subjects given 1800 mg intramuscularly. Levels returned to normal in about 2 weeks.

Local

Local side effects have included mild to moderate injection site pain, 40 to 60 minutes after intramuscular injection.

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