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Photofrin Disease Interactions

There are 3 disease interactions with Photofrin (porfimer).

Major

Porfimer (applies to Photofrin) esophageal fistula

Major Potential Hazard, High plausibility. Applicable conditions: Tracheoesophageal Fistula

The use of photodynamic therapy (PDT) with porfimer is contraindicated for the treatment of esophageal cancer in patients with an existing bronchoesophageal or tracheoesophageal fistula. Prior to administration of PDT, patients must be evaluated by barium swallow to rule out fistulas, which can occur with PDT, particularly if the esophageal tumor is eroding into the trachea or bronchial tree.

References

  1. (2001) "Product Information. Photofrin (porfimer)." Sanofi Winthrop Pharmaceuticals
Major

Porfimer (applies to Photofrin) esophageal varices

Major Potential Hazard, High plausibility.

Treatment with photodynamic therapy and porfimer should be conducted with extreme caution in patients with esophageal varices. Light should not be given directly to the variceal area because of the high risk of bleeding. In general, photodynamic therapy is not suitable for patients with esophageal or gastric varices, or patients with esophageal ulcers >1 cm in diameter.

References

  1. (2001) "Product Information. Photofrin (porfimer)." Sanofi Winthrop Pharmaceuticals
Major

Porfimer (applies to Photofrin) porphyria

Major Potential Hazard, High plausibility.

The use of porfimer is contraindicated in patients with porphyria.

References

  1. (2001) "Product Information. Photofrin (porfimer)." Sanofi Winthrop Pharmaceuticals

Photofrin drug interactions

There are 203 drug interactions with Photofrin (porfimer).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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