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Nilandron Disease Interactions

There are 2 disease interactions with Nilandron (nilutamide).

Major

Nilutamide (applies to Nilandron) hepatic dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease

The use of nilutamide is contraindicated in patients with severe hepatic impairment. Patients with hepatic dysfunction may be at increased risk for nilutamide- associated hepatitis and marked increases in liver enzymes. Nilutamide is extensively metabolized by the liver and the metabolic activity and disposition of nilutamide may be altered in patients with severe hepatic impairment. Patients should be instructed to immediately report any sign or symptoms of hepatic dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Clinical monitoring of hepatic function is recommended and nilutamide should be discontinued if liver transaminase levels increase two to three times the upper limit of normal.

References

  1. (2001) "Product Information. Nilandron (nilutamide)." Hoechst Marion Roussel
  2. Gomez JL, Dupont A, Cusan L (1992) "Simultanwous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med, 92, p. 563-6
  3. Gomez JL, Dupont A, Cusan L (1992) "Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med, 92, p. 563-6
Major

Nilutamide (applies to Nilandron) interstitial pneumonitis

Major Potential Hazard, High plausibility.

The use of nilutamide is contraindicated in patients with severe respiratory impairment. Patients with pulmonary dysfunction may be at increased risk for nilutamide- associated interstitial pneumonitis. Patients should be instructed to immediately report any signs or symptoms of respiratory impairment such as dyspnea, cough, chest pain, or fever. Clinical monitoring of pulmonary function, including pre-treatment chest X-ray, is recommended.

References

  1. (2001) "Product Information. Nilandron (nilutamide)." Hoechst Marion Roussel
  2. Gomez JL, Dupont A, Cusan L (1992) "Simultanwous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med, 92, p. 563-6
  3. Gomez JL, Dupont A, Cusan L (1992) "Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med, 92, p. 563-6
  4. Wieder JA, Soloway MS (1998) "Interstitial pneumonitis associated with neoadjuvant leuprolide and nilutamide for prostate cancer." J Urol, 159, p. 2099
View all 4 references

Nilandron drug interactions

There are 257 drug interactions with Nilandron (nilutamide).

Nilandron alcohol/food interactions

There is 1 alcohol/food interaction with Nilandron (nilutamide).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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